ArticleNutrients2020
Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Role of omega-3 fatty acids in reducing proteinuria: A systematic review and meta-analysis.Asia Pacific journal of clinical nutrition · 2024Pooled it
- Association between meat and fish intake and kidney stone risk: a cross-sectional food frequency questionnaire study in a Chinese population.Frontiers in nutrition · 2026Article
- The research progress and potential applications ofThe British journal of nutrition · 2025Review
- Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults.PloS one · 2025Article
- Host-derivedeLife · 2024Article
- Article
- Virtual screening and activity evaluation of human uric acid transporter 1 (hURAT1) inhibitors.RSC advances · 2023Article
- Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization.Frontiers in immunology · 2023Article
- Moving the Needle in Gout Management: The Role of Culture, Diet, Genetics, and Personalized Patient Care Practices.Nutrients · 2022Review
- Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial.BMC rheumatology · 2022Article
- Article
- Role of diet in hyperuricemia and gout.Best practice & research. Clinical rheumatology · 2021Review
- Nut intake and hyperuricemia risk in young adults.Public health nutrition · 2021Article
- Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The beneficial effects of fatty acids (FAs) on human health have attracted widespread interest. However, little is known about the impact of FAs on the handling of urate, the end-product of human purine metabolism, in the body. Increased serum urate levels occur in hyperuricemia, a disease that can lead to gout. In humans, urate filtered by the glomerulus of the kidney is majorly re-absorbed from primary urine into the blood via the urate transporter 1 (URAT1)-mediated pathway. URAT1 inhibition, thus, contributes to decreasing serum urate concentration by increasing net renal urate excretion. Here, we investigated the URAT1-inhibitory effects of 25 FAs that are commonly contained in foods or produced in the body. For this purpose, we conducted an in vitro transport assay using cells transiently expressing URAT1. Our results showed that unsaturated FAs, especially long-chain unsaturated FAs, inhibited URAT1 more strongly than saturated FAs. Among the tested unsaturated FAs, eicosapentaenoic acid, α-linolenic acid, and docosahexaenoic acid exhibited substantial URAT1-inhibitory activities, with half maximal inhibitory concentration values of 6.0, 14.2, and 15.2 μM, respectively. Although further studies are required to investigate whether the ω-3 polyunsaturated FAs can be employed as uricosuric agents, our findings further confirm FAs as nutritionally important substances influencing human health.
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Registered trials
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