Evidence map›Paper›PMID 32485952›Full record

ArticleViruses2020

Natural History of Aerosol Induced Lassa Fever in Non‑Human Primates.

Isaac L Downs, Carl I Shaia, Xiankun Zeng, Joshua C Johnson, Lisa Hensley, David L Saunders, Franco Rossi, Kathleen A Cashman, Heather L Esham, Melissa K Gregory and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Isaac L DownsUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0002-5106-3832
Carl I ShaiaUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Xiankun ZengUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Joshua C JohnsonUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0002-5677-3841
Lisa HensleyUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
David L SaundersUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Franco RossiUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Kathleen A CashmanUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Heather L EshamUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Melissa K GregoryUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
William D PrattUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
John C TrefryUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Kyle A EversonUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Charles B LarcomMadigan Army Medical Center, Joint Base Lewis‑McChord, WA 98431, USA.
Arthur C OkwesiliUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Anthony P CardileUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Anna HonkoUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0001-9165-148X
United States Army Medical Research Institute of Infectious Diseases · USNational Institutes of Health · USBoston University · USDefense Threat Reduction Agency · USMadigan Army Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lassa virus (LASV), an arenavirus causing Lassa fever, is endemic to West Africa with up to 300,000 cases and between 5000 and 10,000 deaths per year. Rarely seen in the United States, Lassa virus is a CDC category A biological agent inasmuch deliberate aerosol exposure can have high mortality rates compared to naturally acquired infection. With the need for an animal model, specific countermeasures remain elusive as there is no FDA-approved vaccine. This natural history of aerosolized Lassa virus exposure in

Indexed as

AerosolsAnimalsFlow CytometryInhalation ExposureLassa FeverLassa virusMacaca fascicularisMaleReal-Time Polymerase Chain ReactionTelemetryViral Plaque AssayViremiaAerosolsaerosolalkalosisanion gapJosiahLassaLASVmacaquetelemetryVHFvirus

Identifiers

PMID32485952
PMCPMC7354473
OpenAlexW3031293351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.