ReviewInternational journal of molecular sciences2020
Post-Burn Pruritus.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06104540 (Comparison of the Effects of Liquid Vaseline and Olive Oil on Itching and Scarring in Scald Burns), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effects of Liquid Vaseline and Olive Oil on Itching and Scarring in Scald Burns
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- [Practice guideline for adult burn rehabilitation nursing (2026 edition)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Guideline
- Interventions for postburn pruritus.The Cochrane database of systematic reviews · 2024Pooled it
- ML281 Does Not Function as an STK33 Inhibitor but Modulates Proliferation and Differentiation of Keratinocytes Derived from Hypertrophic Scars.International journal of molecular sciences · 2026Article
- The Adjunctive Role of Botulinum Toxin A in Wound Healing and Scar Management.Aesthetic plastic surgery · 2026Review
- Altered sensory neuron activity in a mouse model of post-burn pain and itch.Scientific reports · 2026Article
- Clinical application of 10 600 and 1540 nm laser therapy in post-burn functional impairment: a case report.International journal of surgery case reports · 2026Article
- Post-Burn Itching: Phenomenological Analyses of Patient Views.International wound journal · 2026Article
- Analysis of treatment pathways and long-term prevalence of pruritus after burn - An observational study with real-world data.Burns : journal of the International Society for Burn Injuries · 2026Observational
- Altered sensory neuron activity in a mouse model of post-burn pain and itch.Research square · 2026Article
- The effect of purified hemoglobin spray on the treatment of pediatric patients with second-degree burns.Frontiers in pediatrics · 2026Article
- Patient-Reported Pain and Itch Scores After a Course of Laser Therapy for the Treatment of Postburn Hypertrophic Scar Are Impacted by Mental Health Status.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Scratching the Surface: A Comprehensive Guide to Understanding and Managing Vulvovaginal Itching.American journal of clinical dermatology · 2025Review
- Prevalence and Mechanisms of Itch in Chronic Wounds: A Narrative Review.Journal of clinical medicine · 2025Review
- Pathophysiology and management of burn injury-induced pain.Burns open : an international open access journal for burn injuries · 2025Article
- Managing a Burning Face: Clinical Manifestations and Therapeutic Approaches for Neurogenic Rosacea.International journal of molecular sciences · 2025Review
- Caring for Patients Experiencing Itching After Burns: Phenemonological Analysis of Nurses' Views.International wound journal · 2025Article
- Co-design of an outcome measure for hand burn injuries.The British journal of occupational therapy · 2025Article
- Promising Strategies for the Management of Burn-Wound-Associated Pruritus.European burn journal · 2025Article
- Gray matter volume microstructural alterations in chronic post-burn pruritus: a voxel-based morphometry analysis using 3D T1-weighted imaging.Frontiers in neuroscience · 2025Article
- Burn scar pain: from mechanisms to treatments.Frontiers in physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Many potential treatments are available for pruritus but there is no consensus of the best single treatment yet. The precise mechanism of post-burn pruritus has not been elucidated, but it appears to have pruritogenic and neuropathic aspects. Clinically, post-burn pruritus tends to be intractable to conventional treatment but rather responds to neuroleptic agents, such as gabapentin and pregabalin. During wound healing, various neuropeptides secreted from the nerves of the skin control epidermal and vascular proliferation and connective tissue cells. When keratinocytes are activated by an itch-inducing substance, they secrete a variety of inflammatory substances that increase the susceptibility of the itch receptor. There are two mechanisms underlying post-burn neuropathic pruritus. The first one is peripheral sensitization. The second one is the intact nociceptor hypothesis. An effective treatment for post-burn pruritus will also be effective in other neuropathic and intractable itching. In this review, we summarized the interaction and mechanism of keratinocytes, immune cells, and nerve fibers related to post-burn pruritus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.