Evidence map›Paper›PMID 32485592›Full record

ReviewCurrent opinion in microbiology2020

Systems biology of host-Candida interactions: understanding how we shape each other.

Andrea Hodgins-Davis, Teresa R O'Meara

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrea Hodgins-DavisDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Teresa R O'MearaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. Electronic address: tromeara@umich.edu.

Funding

Global analysis of circuitry governing fungal activation of host inflammationK22AI137299 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMEARA, TERESA R. · 2019 to 2021
$303k
NIAID NIH HHS K22 AI137299
6 · The paper itself

Abstract

Candida albicans is both a member of the human mucosal microbiota and a common agent of invasive fungal disease. Systems biology approaches allow for analysis of the interactions between this fungus and its mammalian host. Framing these studies by considering how C. albicans and its host construct the niche the other occupies provides insight into how these interactions shape the ecosystems, behavior, and evolution of each organism. Here, we discuss recent work on multiscale systems biology approaches for examining C. albicans in relation to the host ecosystem to identify the emergent properties of the interactions and new variables that can be targeted for development of therapeutic strategies.

Indexed as

AnimalsCandida albicansCandidiasisHost-Pathogen InteractionsHumansSystems Biology

Identifiers

PMID32485592
PMCPMC7704567

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.