Evidence map›Paper›PMID 32485062›Full record

ArticlePigment cell & melanoma research2020

Non-invasive optical biopsy by multiphoton microscopy identifies the live morphology of common melanocytic nevi.

Griffin Lentsch, Manuel Valdebran, Inga Saknite, Janellen Smith, Kenneth G Linden, Karsten König, Ronald J Barr, Ronald M Harris, Bruce J Tromberg, Anand K Ganesan and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pigment cell & melanoma research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Optical imaging technologies forCurrent opinion in biomedical engineering · 2023
    Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Griffin LentschBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA.ORCID 0000-0003-2465-9937
Manuel ValdebranDepartment of Dermatology, University of California, Irvine, CA, USA.
Inga SakniteBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA.
Janellen SmithDepartment of Dermatology, University of California, Irvine, CA, USA.
Kenneth G LindenDepartment of Dermatology, University of California, Irvine, CA, USA.
Karsten KönigDepartment of Biophotonics and Laser Technology, Saarland University, Saarbrucken, Germany.
Ronald J BarrDepartment of Dermatology, University of California, Irvine, CA, USA.
Ronald M HarrisDepartment of Dermatology, University of California, Irvine, CA, USA.
Bruce J TrombergBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA.
Anand K GanesanDepartment of Dermatology, University of California, Irvine, CA, USA.ORCID 0000-0003-4944-9274
Christopher B ZacharyDepartment of Dermatology, University of California, Irvine, CA, USA.
Kristen M KellyBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA.
Mihaela BaluBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA.
University of California, Irvine · USJenLab (Germany) · DE

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imagingR01EB026705 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mihaela Balu, Anand K Ganesan · 2018 to 2026
$4.2M
Quantitative multiphoton microscopy for non-invasive diagnosis of melanomaR01CA195466 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALU, MIHAELA, KELLY, KRISTEN M · 2016 to 2018
$825k
NCI NIH HHS P30 CA062203NCI NIH HHS P30CA062203NCI NIH HHS R01CA19546NCI NIH HHS R01 CA195466NIAMS NIH HHS P30 AR075047NIBIB NIH HHS LAMMP, P41-EB015890NIBIB NIH HHS P41 EB015890NIBIB NIH HHS R01 EB026705NIBIB NIH HHS R01EB026705NIH HHS P30AR075047
6 · The paper itself

Abstract

Multiphoton microscopy (MPM) is a promising non-invasive imaging tool for discriminating benign nevi from melanoma. In this study, we establish a MPM morphologic catalogue of common nevi, information that will be critical in devising strategies to distinguish them from nevi that are evolving to melanoma that may present with more subtle signs of malignancy. Thirty common melanocytic nevi were imaged in vivo using MPM. Quantitative parameters that can distinguish between different types of nevi were developed and confirmed by examining the histology of eleven of the imaged nevi. MPM features of nevi examined included cytologic morphology of melanocytes in the epidermis and dermis, the size and distribution of nevomelanocytes both within and around nests, the size of rete ridges, and the presence of immune cells in the dermis. Distinguishing features include cytological morphology, the size of nevomelanocytes, the size of nevomelanocyte nests, and the distribution of nevomelanocytes. Notably, these distinguishing characteristics were not easily appreciated in fixed tissues, highlighting essential differences in the morphology of live skin. Taken together, this work provides a morphologic compendium of normal nevi, information that will be critical in future studies directed at identifying melanocytic nevi that are evolving to melanoma.

Indexed as

Microscopy, Fluorescence, MultiphotonAdultAged, 80 and overBiopsyCell SizeFemaleHumansImmunityMaleMelanocytesMiddle AgedNevus, PigmentedSkin NeoplasmsYoung Adultautofluorescence imagingmelanocytic nevimelanomamultiphoton excitation microscopyoptical microscopypigmented molespigmented nevi

Identifiers

PMID32485062
PMCPMC7687135
OpenAlexW3028642063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.