ArticleJournal of insect science (Online)2020
Silencing of Cytochrome P450 in Spodoptera frugiperda (Lepidoptera: Noctuidae) by RNA Interference Enhances Susceptibility to Chlorantraniliprole.
Article in Journal of insect science (Online), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 77 citations in OpenAlex.
- Resistance monitoring and putative biochemical mechanisms of Spodoptera frugiperda to different insecticides in China.Pest management science · 2026Article
- UDP-glycosyltransferase confers anthranilic diamide resistance in Bemisia tabaci.Journal of advanced research · 2026Article
- Review
- miR-10-5p mediated susceptibility to chlorantraniliprole by targeting for SfGSTe1 in Spodoptera frugiperda (Smith).Scientific reports · 2025Article
- The Molecular Mechanisms Underlying Zucchini-Induced Changes in the Host Adaptation of Cotton- and Cucumber-TypeBiomolecules · 2025Article
- Nuclear genome assembly of Leucinodes orbonalis (Lepidoptera: Crambidae) collected from the Philippines.Journal of insect science (Online) · 2025Article
- Divergent Selection Promotes Intraspecific Genomic Differentiation inEcology and evolution · 2025Article
- Self-assembled co-delivery nanoplatform for increasing the broad-spectrum susceptibility of fall armyworm toward insecticides.Journal of advanced research · 2025Article
- Two host-plant strains in the fall armyworm.Insect science · 2024Review
- Physiological and Molecular Mechanisms of Lepidopteran Insects: Genomic Insights and Applications of Genome Editing for Future Research.International journal of molecular sciences · 2024Review
- Genome-wide identification, molecular evolution and gene expression of P450 gene family in Cyrtotrachelus buqueti.BMC genomics · 2024Article
- Invasive fall armyworms are corn strain.Scientific reports · 2024Article
- Identification of differentially expressed miRNAs associated with diamide detoxification pathways in Spodoptera frugiperda.Scientific reports · 2024Article
- Article
- Knockdown ofFrontiers in physiology · 2024Article
- Resistance monitoring and mechanism in the fall armywormFrontiers in physiology · 2023Article
- Article
- Stabilized Double-Stranded RNA Strategy Improves Cotton Resistance to CBW (International journal of molecular sciences · 2022Article
- Effects of Elevated COInsects · 2022Article
- Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fall armyworm, Spodoptera frugiperda (Smith), has caused significant losses for crop production in China. The fall armyworm is mainly controlled by the chemical insecticides, whereas the frequent application of insecticides would result in the resistance development. Insect cytochrome P450 monooxygenases play an essential part in the detoxification of insecticides. In this study, five P450 genes were selected to determine the role in response to insecticides by RNA interference (RNAi). Developmental expression pattern analysis revealed that S. frugiperda CYP321A8, CYP321A9, and CYP321B1 were highest in second-instar larvae among developmental stages, with 2.04-, 3.39-, and 8.58-fold compared with eggs, whereas CYP337B5 and CYP6AE44 were highest in adult stage, with 16.3- and 10.6-fold in comparison of eggs, respectively. Tissue-specific expression pattern analysis exhibited that CYP321A8, CYP321B1, and CYP6AE44 were highest in the midguts, with 3.56-, 3.33-, and 3.04-fold compared with heads, whereas CYP321A9 and CYP337B5 were highest in wings, with 3.07- and 3.36-fold compared with heads, respectively. RNAi was also conducted to explore detoxification effects of the five P450 genes on chlorantraniliprole. The second-instar larvae became more sensitive to chlorantraniliprole with a higher mortality rate than the control, after silencing CYP321A8, CYP321A9, and CYP321B1, respectively. These findings strongly supported our viewpoint that CYP321A8, CYP321A9, and CYP321B1 may play a critical role in insecticide detoxification. It will provide a basis for further study on regulation of P450 genes and the management of S. frugiperda.
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