Evidence map›Paper›PMID 32484651›Full record

ArticleACS nano2020

Phospholipase A

Sonia Kartha, Lesan Yan, Meagan E Ita, Ahmad Amirshaghaghi, Lijun Luo, Yulong Wei, Andrew Tsourkas, Beth A Winkelstein, Zhiliang Cheng

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Pathophysiology-Directed Engineering of a Combination Nanoanalgesic for Neuropathic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sonia KarthaDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.
Lesan YanDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-3616-9628
Meagan E ItaDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.
Ahmad AmirshaghaghiDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.
Lijun LuoDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.
Yulong WeiDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-7758-1753
Beth A WinkelsteinDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-0414-0484
Zhiliang ChengDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-3351-6874
University of Pennsylvania · USHospital of the University of Pennsylvania · US

Funding

Targeted treatment for radiculopathy via engineered PLA2-responsive multifunctional micellesR01NS100892 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHENG, ZHILIANG · 2017 to 2021
$1.7M
NINDS NIH HHS R01 NS100892
6 · The paper itself

Abstract

Treating persistent neuropathic pain remains a major clinical challenge. Current conventional treatment approaches carry a substantial risk of toxicity and provide only transient pain relief. In this work, we show that the activity and expression of the inflammatory mediator secretory phospholipase-A

Indexed as

MicellesNeuralgiaHumansPhospholipases A2PhospholipidsMicellesPhospholipases A2Phospholipidsinflammationinhibitorneuropathic painphospholipasephospholipid micelles

Identifiers

PMID32484651
PMCPMC7438274
OpenAlexW3031737983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.