Evidence map›Paper›PMID 32484592›Full record

ArticleBritish journal of pharmacology2020

Silencing of spontaneous activity at α4β1/3δ GABA

Nils Ole Dalby, Christina Birkedahl Falk-Petersen, Ulrike Leurs, Petra Scholze, Jacob Krall, Bente Frølund, Petrine Wellendorph

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Preventing Phosphorylation of the GABAFrontiers in molecular neuroscience · 2022
    Article
  4. Article
  5. Silencing of spontaneous activity at α4β1/3δ GABABritish journal of pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nils Ole DalbyDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1901-4205
Christina Birkedahl Falk-PetersenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8576-9406
Ulrike LeursDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8828-3505
Petra ScholzeDepartment of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4984-6034
Jacob KrallDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7452-3459
Bente FrølundDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5476-6288
Petrine WellendorphDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5455-8013
University of Copenhagen · DKMedical University of Vienna · AT

Funding

Lundbeck Foundation R133-A12270Lundbeck Foundation R192-2015-666Lundbeck Foundation R230-2016-2562
6 · The paper itself

Abstract

background and purposeThe δ-subunit-containing GABA EXPERIMENTAL APPROACH: Whole-cell electrophysiological recordings of adult male rat and mouse hippocampal DGGCs were used to characterize known agonists and antagonists at δ-subunit-containing GABA KEY

resultsRecordings at either 24°C or 34°C, including the PKC autoinhibitory peptide (19-36) intracellularly, removed spontaneous gating by GABA CONCLUSION AND IMPLICATIONS: Kinase activity infers spontaneous gating in α

Indexed as

NeuronsReceptors, GABA-AAnimalsgamma-Aminobutyric AcidHippocampusLigandsMaleMiceRatsgamma-Aminobutyric AcidLigandsReceptors, GABA-A

Identifiers

PMID32484592
PMCPMC7429488
OpenAlexW3032193554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.