Evidence map›Paper›PMID 32484284›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Applications of CRISPR technologies in transplantation.

Cem Kuscu, Canan Kuscu, Amandeep Bajwa, James D Eason, Daniel Maluf, Valeria R Mas

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Cellular and Molecular Aspects of Chronic Rejection.Results and problems in cell differentiation · 2026
    Review
  3. Beyond preservation: future machine perfusion for liver assessment and repair.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  4. Review
  5. Review
  6. Human gene therapy · 2024
    Review
  7. Review
  8. Developments in kidney xenotransplantation.Frontiers in immunology · 2023
    Review
  9. Editorial:Frontiers in surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cem KuscuDepartment of Surgery, School of Medicine, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0001-7154-6762
Canan KuscuDepartment of Surgery, School of Medicine, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Amandeep BajwaDepartment of Surgery, School of Medicine, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
James D EasonDepartment of Surgery, School of Medicine, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Daniel MalufDepartment of Surgery, School of Medicine, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0002-5921-4834
Valeria R MasDepartment of Surgery, School of Medicine, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
University of Tennessee Health Science Center · US

Funding

Assessment of Donor Quality for Improving Kidney Transplant OutcomesR01DK109581 · NIDDK · UNIVERSITY OF VIRGINIA · PI Kellie J. Archer, Valeria Raquel Mas · 2017 to 2026
$4.0M
Dissecting the role of dynamic epigenome prompting pathways leading to kidney allograft fibrosisR01DK122682 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MAS, VALERIA RAQUEL · 2019 to 2023
$3.6M
Molecular pathways leading to chronic graft dysfunctionR01DK080074 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI MAS, VALERIA RAQUEL · 2008 to 2012
$1.8M
Mitochondrial Therapy for Kidney InjuryR01DK117183 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BAJWA, AMANDEEP · 2018 to 2022
$1.7M
NIDDK NIH HHS R01 DK080074NIDDK NIH HHS R01DK080074NIDDK NIH HHS R01 DK109581NIDDK NIH HHS R01DK109581NIDDK NIH HHS R01 DK117183NIDDK NIH HHS R01DK117183NIDDK NIH HHS R01 DK122682NIDDK NIH HHS RO1DK122682
6 · The paper itself

Abstract

In transplantation, the ever-increasing number of an organ's demand and long-term graft dysfunction constitute some of the major problems. Therefore, alternative solutions to increase the quantity and quality of the organ supply for transplantation are desired. On this subject, revolutionary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology holds enormous potential for the scientific community with its expanding toolbox. In this minireview, we summarize the history and mechanism of CRISPR/Cas9 systems and explore its potential applications in cellular- and organ-level transplantation. The last part of this review includes future opportunities as well as the challenges in the transplantation field.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsOrgan Transplantationanimal models: porcinebasic (laboratory) research/sciencegenomicsimmunosuppression/immune modulationmolecular biologytolerance: chimerismtranslational research/sciencexenoantigenxenotransplantation

Identifiers

PMID32484284
PMCPMC8109183
OpenAlexW3031444556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.