Evidence map›Paper›PMID 32484226›Full record

ArticleActa biochimica et biophysica Sinica2020

Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells in the repair of diabetic foot ulcers in rats.

Rongfeng Shi, Weishuai Lian, Yinpeng Jin, Chuanwu Cao, Shilong Han, Xiaohu Yang, Suming Zhao, Maoquan Li, Hui Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Rongfeng ShiDepartment of Interventional Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Weishuai LianDepartment of Interventional & Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
Yinpeng JinShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Chuanwu CaoDepartment of Interventional & Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
Shilong HanDepartment of Interventional & Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
Xiaohu YangDepartment of Interventional Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Suming ZhaoDepartment of Interventional Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Maoquan LiDepartment of Interventional & Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
Hui ZhaoDepartment of Interventional Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Tongji University · CNAffiliated Hospital of Nantong University · CNNantong University · CNShanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcer (DFU) is one of diabetic complications, which is frequently present and tormented in diabetes mellitus. Most multipotent mesenchymal stromal cells (MSCs) are capable of immune evasion, providing an allogeneic, ready-to-use, cell product option for therapeutic applications. The beneficial effect of MSCs for the treatment of a variety of traumatic injuries, such as open wounds, has been extensively explored. In this study, a rat DFU model was used to simulate the pathophysiology of clinical patients and to investigate the localization of human umbilical cord mesenchymal stem cells (hUC-MSCs) after intravenous transplantation and its role in DFU healing, so as to evaluate the potential of hUC-MSCs in the treatment of DFU. The diabetic rat model was established by streptozotocin injection, which was used to create full-thickness foot dorsal skin wounds to mimic DFU by a 6-mm skin biopsy punch and a Westcott scissor. The hUC-MSCs were transplanted through femoral vein, and the ulcer cicatrization situation and the fate of hUC-MSCs were evaluated. Our data suggest that intravenously transplantated hUC-MSCs have the ability to migrate and locate to the wound tissue and are helpful to wound healing in DFU rats, partly by regulating inflammation, trans-differentiation and providing growth factors that promote angiogenesis, cell proliferation and collagen deposition. Herein, we demonstrate that hUC-MSC transplantation is able to accelerate DFU healing in rats and transplantation of exogenous stem cells may be a potential strategy for clinical application in DFUs.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic FootMesenchymal Stem Cell TransplantationAnimalsFemaleHeterograftsHumansMesenchymal Stem CellsRatsRats, Sprague-DawleyUmbilical Veinsdiabetic foot ulcerhuman umbilical cord mesenchymal stem cellstissue repair

Identifiers

PMID32484226
PMCPMC7333920
OpenAlexW3032527021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.