ArticleThe American journal of tropical medicine and hygiene2020
Malaria and Parasitic Neglected Tropical Diseases: Potential Syndemics with COVID-19?
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05746819 (An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial), which is not on this map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)
Who cites it
66 citing papers in PubMed, 116 citations in OpenAlex.
- Sex in Immune Cells and Parasitic Diseases - A Complex Relationship.Immunological reviews · 2026Review
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- Global epidemiological trends, distribution of NTDs and malaria, and disease burden projections for the next 15 years.Frontiers in public health · 2026Article
- Sex-specific hemostatic responses and alterations of Platelet Distribution Width (PDW) and D-dimer in mild COVID-19, Malaria, and co-infection in a tropical setting: A case-control study in Port Harcourt, Nigeria.PLOS global public health · 2026Article
- Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Resilience of long-lasting insecticidal net distribution system on the Thai-Myanmar border: pre, during, and post COVID-19 pandemic insights.Malaria journal · 2025Article
- Applications and research trends in organoid based infectious disease models.Scientific reports · 2025Review
- Enhanced data quality to improve malaria surveillance in Papua, Indonesia.Malaria journal · 2025Article
- ROY Crystallization on Poly(ethylene) Fibers, a Model for Bed Net Crystallography.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Exploring the hidden mental health consequences of malaria beyond the fever.Frontiers in human neuroscience · 2024Review
- Review
- Malaria in adults after the start of Covid-19 pandemic: an analysis of admission trends, demographics, and outcomes in a tertiary hospital in the Gambia.Malaria journal · 2023Article
- Prevalence of asymptomatic strongyloidiasis co-infection in COVID-19 patients residing in endemic areas.European journal of medical research · 2023Article
- Immediate and long-term changes in infectious diseases in China at the "First-level-response", "Normalized-control" and "Dynamic-COVID-zero" stages from 2020 to 2022: a multistage interrupted-time-series-analysis.BMC public health · 2023Article
- Importance of Balanced Attention Toward Coronavirus Disease 2019 and Neglected Tropical Diseases.Yonsei medical journal · 2023Review
- Association of Toxoplasmosis and COVID-19 in a MexicanPopulation.Microorganisms · 2023Article
- Co-infection of COVID-19 and parasitic diseases: A systematic review.Parasite epidemiology and control · 2023Review
- The Impact of COVID-19 Pandemic on Arthropod-Related Diseases.Journal of arthropod-borne diseases · 2023Review
- Pandemic justice for and from Latin America.Ethic@ : an international journal for moral philosophy = Revista internacional de filosofia da moral · 2023Article
- Proposing a New Conceptual Syndemic Framework for COVID-19 Vaccine Hesitancy: A Narrative Review.International journal of environmental research and public health · 2023Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic, caused by SARS-CoV-2, have surpassed 5 million cases globally. Current models suggest that low- and middle-income countries (LMICs) will have a similar incidence but substantially lower mortality rate than high-income countries. However, malaria and neglected tropical diseases (NTDs) are prevalent in LMICs, and coinfections are likely. Both malaria and parasitic NTDs can alter immunologic responses to other infectious agents. Malaria can induce a cytokine storm and pro-coagulant state similar to that seen in severe COVID-19. Consequently, coinfections with malaria parasites and SARS-CoV-2 could result in substantially worse outcomes than mono-infections with either pathogen, and could shift the age pattern of severe COVID-19 to younger age-groups. Enhancing surveillance platforms could provide signals that indicate whether malaria, NTDs, and COVID-19 are syndemics (synergistic epidemics). Based on the prevalence of malaria and NTDs in specific localities, efforts to characterize COVID-19 in LMICs could be expanded by adding testing for malaria and NTDs. Such additional testing would allow the determination of the rates of coinfection and comparison of severity of outcomes by infection status, greatly improving the understanding of the epidemiology of COVID-19 in LMICs and potentially helping to mitigate its impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.