Evidence map›Paper›PMID 32483758›Full record

ArticleDoklady. Biochemistry and biophysics2020

Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse.

S D Varfolomeev, V I Bykov, S B Tsybenova

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

S D VarfolomeevInstitute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intellegence, Moscow State University, 119991, Moscow, Russia.
V I BykovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia. vibykov@mail.ru.
S B TsybenovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.
Institute of Biochemical Physics NM Emanuel · RULomonosov Moscow State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A kinetic model describing the dynamics of synaptic "discharge" taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs.

Indexed as

Acetic AcidAcetylcholineAcetylcholinesteraseBrainCholineCholinergic AgentsCholinesterase InhibitorsHumansHydrogen-Ion ConcentrationKineticsNeuromuscular JunctionNeuronsNeurotoxinsNeurotransmitter AgentsPesticidesProtonsAcetic AcidAcetylcholineAcetylcholinesteraseCholineCholinergic AgentsCholinesterase InhibitorsNeurotoxinsNeurotransmitter AgentsPesticidesProtonsReceptors, Cholinergicacetylcholineacetylcholinesterasecatalytic activity of enzymecholinergic synapsedynamics of the processhuman brainkinetic modelneuromuscular junctionsynaptic cleft

Identifiers

PMID32483758
OpenAlexW3031438629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.