Evidence map›Paper›PMID 32483710›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2020

Changes in the Activity of Genes Involved in the Regulation of Hematopoiesis during Tumorigenesis in Irradiated Mice.

D V Saleeva, V F Mikhailov, L M Rozhdestvenskii, L V Shulenina, N F Raeva, G D Zasukhina

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D V SaleevaBurnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia. dasha_sleeva@inbox.ru.
V F MikhailovBurnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia.
L M RozhdestvenskiiBurnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia.
L V ShuleninaBurnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia.
N F RaevaBurnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia.
G D ZasukhinaBurnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia.
Federal Medical-Biological Agency · RUVavilov Institute of General Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used 183 F1 CBA×C57Bl hybrid mice to study the delayed effects of low-power long-term γ-irradiation at a dose of 12.6 Gy (10 mGy/min) 8 and 10 months after the treatment. Eight months after the treatment we found the increased expression of the transcription factor NFκB and its target genes iNOS and G-SCF in the bone marrow (BM). Ten months after the treatment malignant lymphomas were revealed in 14 of 94 mice in the liver, abdominal cavity, and subcutaneously. In the BM of these mice, the transcription of the PTEN, NFκB, and iNOS genes was inhibited and the contents of long non-coding RNAs (lncRNAs) lnc p21, NEAT1, and microRNA miR-125b were decreased. The expression of the NFκB(p65) gene and miR-125b was inhibited in the BM of irradiated mice without tumors ten months after the treatment. These data show the deregulation of the P53 system supporting the genome stability in the BM of irradiated mice. These indices will be studied as potential markers of risk of development of irradiation-induced tumors.

Indexed as

AnimalsBone MarrowGamma RaysGene Expression RegulationHematopoiesisMaleMice, Inbred C57BLMice, Inbred CBAMicroRNAsNeoplasms, Radiation-InducedNF-kappa BNitric Oxide Synthase Type IIPTEN PhosphohydrolaseRNA, Long NoncodingMicroRNAsNF-kappa BNitric Oxide Synthase Type IINos2 protein, mousePTEN PhosphohydrolasePten protein, mouseRNA, Long Noncodingdelayed effects of irradiationlncRNAlymphomamicroRNANFκBP53γ-irradiation

Identifiers

PMID32483710
OpenAlexW3028885013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.