Evidence map›Paper›PMID 32483708›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2020

The Mechanism of the Stimforte Effect on the Activation of Target Cell Defense against Viral Infection.

D G Mal'dov, P G Deryabin, S S Grigoryan, D V Mishin, V L Andronova, E I Isaeva, G A Galegov, A V Ilichev

Abstract read
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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

D G Mal'dovZAO SKY LTD, 129301, Moscow, Russia. maldov-dg@yandex.ru.
P G DeryabinGamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
S S GrigoryanGamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
D V MishinGamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
V L AndronovaGamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
E I IsaevaGamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
G A GalegovGamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
A V IlichevZAO SKY LTD, 129301, Moscow, Russia.
D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences · RUMinistry of Health of the Russian Federation · RUMoscow Polytechnic University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimforte in a wide range of concentrations (15-225 µg/mL) totally inhibits the cytopathic activity of hepatitis C virus (HCV) in the Vero-V cell culture. Interferons (IFN) play the most important role in the suppression of infection when the drug is introduced into the culture before the infection. When Stimforte is introduced after the infection, the mechanism of action seems to be different. The activators of IFN production are mainly (or exclusively) the ligands of receptor complexes TLR-4 and NOD-2 contained in the drug. The action of these substances is probably synergistic, similar to the action of LPS and MDP in Vero-V cells.

Indexed as

Acetylmuramyl-Alanyl-IsoglutamineAdjuvants, ImmunologicAnimalsAntiviral AgentsCell SurvivalChlorocebus aethiopsDose-Response Relationship, DrugHepacivirusHepatitis CInterferonsLipopolysaccharidesNod2 Signaling Adaptor ProteinOrganic ChemicalsToll-Like Receptor 4Vero CellsVirus ReplicationAcetylmuramyl-Alanyl-IsoglutamineAdjuvants, ImmunologicAntiviral AgentsInterferonsLipopolysaccharidesNod2 Signaling Adaptor ProteinOrganic ChemicalsstimforteToll-Like Receptor 4hepatitis C virusinterferon productionin vitro virus suppressionStimforteTLR-4 and NOD-2 receptorsVero-V cells

Identifiers

PMID32483708
OpenAlexW3029729440

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.