ArticleBasic and clinical neuroscience
Evaluating the Antidepressant Effect of Verbena officinalis L. (Vervain) Aqueous Extract in Adult Rats.
Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Article
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- Therapeutics to Treat Psychiatric and Neurological Disorders: A Promising Perspective from Algerian Traditional Medicine.Plants (Basel, Switzerland) · 2023Review
- Metabolic Profiling by GC-MS,Molecules (Basel, Switzerland) · 2022Article
- In Vitro Antimelanoma Properties ofMolecules (Basel, Switzerland) · 2022Article
- Hydroalcoholic Extract ofIranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe present study aimed to investigate the antidepressant effect of Verbena (V.) officinalis L. aqueous extract in adult female rats.
methodsThe present study evaluated the antidepressant effect of V. officinalis L. aqueous (V AE) extract in female rats using the Forced-Swimming Test (FST), Light-Dark Box (LDB) test, and Open Field Test (OFT). The level of glycemia and histological analysis were also studied. The VAE [200 mg/kg Parenterally (PO)] was administered orally for 7 successive days in the separate groups of rats.
resultsThe oral administration of V. officinalis L. aqueous extract significantly decreased (P< 0.01) the immobility time in the FST, increased the time spent in the light area (LDB), and the number of entry into the central squares (OFT). Thus, the extract at a dose of 200 mg/kg significantly decreased the glycemia level (P<0.05) and suggested no harmful effect on brain histology.
conclusionVerbena officinalis L. aqueous extract at a dose of 200 mg/kg could have an anti-depressant effect in adult rats.
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