Evidence map›Paper›PMID 32483454›Full record

ArticleTheranostics2020

Phage-delivered sensitisation with subsequent antibiotic treatment reveals sustained effect against antimicrobial resistant bacteria.

Hongbo Liu, Hao Li, Yuan Liang, Xinying Du, Chaojie Yang, Lang Yang, Jing Xie, Rongtao Zhao, Yigang Tong, Shaofu Qiu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Sensitizing carbapenem-resistant Klebsiella pneumoniae using a compact Cascade-Cas3 system.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  3. Review
  4. Giving Antibiotics a Second Chance: Evolutionary Trade-Offs and Phage-Driven Restoration of Antibiotic Susceptibility.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  5. Prophages in Skin Pathogens: From Virulence to Therapy.Pathogens (Basel, Switzerland) · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Phage-antibiotic synergy attenuatesFrontiers in cellular and infection microbiology · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. OvercomingAntibiotics (Basel, Switzerland) · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Challenges and opportunities of phage therapy forApplied and environmental microbiology · 2024
    Review
  19. Review
  20. CRISPR-Cas System: A New Dawn to Combat Antibiotic Resistance.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hongbo LiuAcademy of Military Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China.
Hao LiState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Yuan LiangThe Centre for Infectious Disease Control, Chinese PLA Centre for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Xinying DuThe Centre for Infectious Disease Control, Chinese PLA Centre for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Chaojie YangThe Centre for Infectious Disease Control, Chinese PLA Centre for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Lang YangAcademy of Military Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China.
Jing XieThe Centre for Infectious Disease Control, Chinese PLA Centre for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Rongtao ZhaoThe Centre for Infectious Disease Control, Chinese PLA Centre for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Yigang TongBeijing Advanced Innovation Center for Soft Matter Science and Engineering (BAIC-SM), College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Shaofu QiuThe Centre for Infectious Disease Control, Chinese PLA Centre for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Hongbin SongAcademy of Military Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China.
Academy of Military Medical Sciences · CNBeijing University of Chemical Technology · CNInstitute of Microbiology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temperate phages integrated with clustered regularly interspaced short palindromic repeat (CRISPR)/Cas systems have been gaining attention as potential strategies for combating bacteria resistant to antimicrobials. To further advance this technology, phage recombination procedure should be improved, and the bactericidal effect should be examined in detail and compared with conventional lytic phage strategy. The possibility of the emergence of mutational resistance, a phenomenon commonly observed with lytic phage therapy, should be illustrated.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriophagesCRISPR-Cas SystemsDisease Models, AnimalDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsFemaleLysogenyMiceMice, Inbred BALB CAnti-Bacterial AgentsAntimicrobial resistanceCRISPR/CasPhage delivery systemPhage genome recombinationPhage therapy

Identifiers

PMID32483454
PMCPMC7255016
OpenAlexW3026446570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.