Evidence map›Paper›PMID 32483421›Full record

ArticleTheranostics2020

The tumor targeting performance of anti-CD166 Probody drug conjugate CX-2009 and its parental derivatives as monitored by

Marion Chomet, Maxime Schreurs, Margaret Nguyen, Bruce Howng, Ruth Villanueva, Michael Krimm, Olga Vasiljeva, Guus A M S van Dongen, Danielle J Vugts

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Praluzatamab Ravtansine, a CD166-Targeting Antibody-Drug Conjugate, in Patients with Advanced Solid Tumors: An Open-Label Phase I/II Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Trial
  2. Review
  3. Journal of pharmaceutical analysis · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Exploring the next generation of antibody-drug conjugates.Nature reviews. Clinical oncology · 2024
    Review
  9. Evaluation of Chelator-to-Antibody Ratio on Development ofInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. Radionuclide-based theranostics - a promising strategy for lung cancer.European journal of nuclear medicine and molecular imaging · 2023
    Review
  12. Article
  13. Article
  14. Antibody-Drug Conjugates for Melanoma and Other Skin Malignancies.Current treatment options in oncology · 2022
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Marion ChometAmsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Maxime SchreursAmsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Margaret NguyenCytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Bruce HowngCytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Ruth VillanuevaCytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Michael KrimmCytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Olga VasiljevaCytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Guus A M S van DongenAmsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Danielle J VugtsAmsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
CytomX Therapeutics (United States) · USVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probody

Indexed as

Activated-Leukocyte Cell Adhesion MoleculeAnimalsAntibodies, MonoclonalCell Line, TumorDisease Models, AnimalFemaleImmunoconjugatesLung NeoplasmsMaytansineMiceMice, NudePositron-Emission TomographyPositron Emission Tomography Computed TomographyProdrugsRadioisotopesRadiopharmaceuticalsActivated-Leukocyte Cell Adhesion MoleculeAntibodies, MonoclonalImmunoconjugatesMaytansineProdrugsRadioisotopesRadiopharmaceuticalsZirconium

Identifiers

PMID32483421
PMCPMC7255005
OpenAlexW3021957536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.