Ruthenium-catalysed multicomponent synthesis of the 1,3-dienyl-6-oxy polyketide motif.

Barry M Trost, James J Cregg, Christoph Hohn, Wen-Ju Bai, Guoting Zhang, Jacob S Tracy

Abstract read

In one paragraph

Article in Nature chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

2.3field-weighted citation impact, top 11% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 29 citations in OpenAlex.

Asymmetric multifunctionalization of alkynes via photo-irradiated organocatalysis.Science advances · 2022
Article
Rhodium-catalyzed intermolecular enantioselective Alder-ene type reaction of cyclopentenes with silylacetylenes.Nature communications · 2021
Article
Organocatalytic Synthesis of α-Trifluoromethyl Allylboronic Acids by Enantioselective 1,2-Borotropic Migration.Journal of the American Chemical Society · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Barry M TrostDepartment of Chemistry, Stanford University, Stanford, CA, USA. BMTrost@stanford.edu.ORCID http://orcid.org/0000-0001-7369-9121

James J CreggDepartment of Chemistry, Stanford University, Stanford, CA, USA.

Christoph HohnDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2406-7683

Wen-Ju BaiDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1412-8673

Guoting ZhangDepartment of Chemistry, Stanford University, Stanford, CA, USA.

Jacob S TracyDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9261-7865

Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyketide natural products are an important class of biologically active compounds. Although substantial progress has been made on the synthesis of repetitive polyketide motifs through the iterative application of a single reaction type, synthetic access to more diverse motifs that require more than one type of carbon-carbon bond connection remains a challenge. Here we describe a catalytic, multicomponent method for the synthesis of the privileged polyketide 1,3-dienyl-6-oxy motif. The method allows for the formation of two new carbon-carbon bonds and two stereodefined olefins. It generates products that contain up to three contiguous sp

Identifiers

PMID32483385

DOI10.1038/s41557-020-0464-x

OpenAlexW3030709006

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.