ArticleNature2020
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 3 pooled it
24.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 3 syntheses or guidelines pooled it, 331 citations in OpenAlex.
- Gut microbiota and ALS: cause, consequence or correlation? - a systematic review.Frontiers in neuroscience · 2026Pooled it
- The Role of Short-Chain Fatty Acids in Microbiota-Gut-Brain Cross-Talk with a Focus on Amyotrophic Lateral Sclerosis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- The risk of dementia in patients with inflammatory bowel disease: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis.International journal of molecular sciences · 2021Trial
- Review
- Gut Microbiota Modulation in CNS Disorders: Therapeutic Strategies and Implications for Drug Efficacy.Molecular neurobiology · 2026Review
- Lysosomal dysfunction in neurodegenerative disease.Nature reviews. Neurology · 2026Review
- A new paradigm of bidirectional regulation of the gut-spinal cord axis.Neural regeneration research · 2026Article
- The Gut-Immune-Brain Axis in Aging: Integrating Immunosenescence, Inflammaging, and Neuroinflammation for Precision Medicine.Medical sciences (Basel, Switzerland) · 2026Review
- TDP-43-immunity-microbiota axis in amyotrophic lateral sclerosis: A potential pathogenic mechanism.Neural regeneration research · 2026Article
- Conference proceedings from the Western Canadian Neuromuscular Conference (WCNMC) - September 27-29, 2024, Calgary, Canada.Journal of neuromuscular diseases · 2026Article
- The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.The EMBO journal · 2026Article
- Targeting the Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.Clinical and translational gastroenterology · 2026Review
- Microbiota as a regulator of brain vulnerability across lifespan and disease contexts.Journal of neuroinflammation · 2026Review
- Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model.Cell reports methods · 2026Article
- Visible Photosensitizing Disinfectant Spray for Combating Multidrug-ResistantExploration (Beijing, China) · 2026Article
- A microbiome quantitative trait locus in SLC39A8 modulates disease severity in synucleinopathy-induced models of Parkinson's disease.Human molecular genetics · 2026Article
- C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen.Cell reports · 2026Article
- Gut microbiota and Parkinson's disease: exploring pathogenesis and potential therapeutic strategies from a gut-brain axis perspective.iScience · 2026Review
- Amyotrophic Lateral Sclerosis: The State of the Art on Treatments and the Therapeutic Role of the Intestinal Microbiome in Human Studies.International journal of molecular sciences · 2026Review
120 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 3 countries.
Aaron BurberryHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1552-8695
Michael F WellsHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Francesco LimoneHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Alexander CoutoHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Kevin S SmithHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
James KeaneyNeuroscience Therapeutic Area, New Medicines, UCB Biopharma SPRL, Braine-l'Alleud, Belgium.
Gaëlle GilletNeuroscience Therapeutic Area, New Medicines, UCB Biopharma SPRL, Braine-l'Alleud, Belgium.
Nick van GastelHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Jin-Yuan WangHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Olli PietilainenHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Menglu QianHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Pierce EgganHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Christopher CantrellHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Joanie MokHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Irena KadiuNeuroscience Therapeutic Area, New Medicines, UCB Biopharma SPRL, Braine-l'Alleud, Belgium.
David T ScaddenHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Kevin EgganHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Eggan@mcb.harvard.edu.ORCID http://orcid.org/0000-0003-4436-8467
Broad Institute · USUCB Pharma (Belgium) · BEHarvard University · US
Funding
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Fernando Camargo · 2017 to 2026
$24.6MC9ORF72 in Motor System Biology and ALSR01NS089742 · NINDS · HARVARD UNIVERSITY · PI EGGAN, KEVIN C · 2014 to 2018
$2.3MThe role of autism susceptibility genes in the 16p11.2 locus on the development and function of human stem cell-derived neural cellsR00MH119327 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WELLS, MICHAEL FREDERICK · 2022 to 2024
$747kExploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral SclerosisR00AG057808 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BURBERRY, AARON · 2021 to 2023
$747kThe role of autism susceptibility genes in the 16p11.2 locus on the development and function of human stem cell-derived neural cellsK99MH119327 · NIMH · BROAD INSTITUTE, INC. · PI WELLS, MICHAEL FREDERICK · 2019 to 2021
$227kExploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral SclerosisK99AG057808 · NIA · HARVARD UNIVERSITY · PI BURBERRY, AARON · 2018 to 2019
$217kNHLBI NIH HHS P01 HL131477NIA NIH HHS K99 AG057808NIA NIH HHS R00 AG057808NIH HHS 1K99MH119327-01NIH HHS 5K99AG057808-02NIH HHS 5R01NS089742NIMH NIH HHS K99 MH119327NIMH NIH HHS R00 MH119327NINDS NIH HHS R01 NS089742
Abstract
A hexanucleotide-repeat expansion in C9ORF72 is the most common genetic variant that contributes to amyotrophic lateral sclerosis and frontotemporal dementia
Indexed as
Brain-Gut AxisC9orf72 ProteinGastrointestinal MicrobiomeGliosisInflammationSpinal CordAmyotrophic Lateral SclerosisAnimalsAnti-Bacterial AgentsAutoimmunityCell MovementCytokinesDisease Models, AnimalFecal Microbiota TransplantationFemaleFrontotemporal DementiaAnti-Bacterial AgentsC9orf72 ProteinC9orf72 protein, mouseCytokines
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.