Evidence map›Paper›PMID 32483360›Full record

ArticleNature medicine2020

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.

Asaf Zviran, Rafael C Schulman, Minita Shah, Steven T K Hill, Sunil Deochand, Cole C Khamnei, Dillon Maloney, Kristofer Patel, Will Liao, Adam J Widman and 32 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06040632 (Accurate Allocation of Completion Resection in Early Colorectal Cancer), which is not on this map. Cited by 264 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 6 pooled it
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06040632 active not recruitingnot on this mapstarted 2022, after this paper: background citation

Accurate Allocation of Completion Resection in Early Colorectal Cancer: an Observational Cohort Study

TypeobservationalSponsorUniversity of AarhusRan2022 to 2027Enrolled67ConditionsColorectal Cancer, Colorectal Polyp, Colorectal Cancer Stage I
3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 6 syntheses or guidelines pooled it, 422 citations in OpenAlex.

  1. Pooled it
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  15. Liquid biopsy in bladder cancer: towards precision oncology.Journal of translational medicine · 2026
    Review
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  17. Article
  18. Article
  19. Article
  20. Review

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 6 institutions in 1 country.

Asaf Zviran *New York Genome Center, New York, NY, USA.
Rafael C Schulman *New York Genome Center, New York, NY, USA.
Minita Shah *New York Genome Center, New York, NY, USA.
Steven T K HillNew York Genome Center, New York, NY, USA.
Sunil DeochandNew York Genome Center, New York, NY, USA.
Cole C KhamneiNew York Genome Center, New York, NY, USA.
Dillon MaloneyNew York Genome Center, New York, NY, USA.
Kristofer PatelNew York Genome Center, New York, NY, USA.
Will LiaoNew York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7574-4694
Adam J WidmanNew York Genome Center, New York, NY, USA.
Phillip WongDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Margaret K CallahanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gavin HaDivision of Public Health Services, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7578-7272
Sarah ReedBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2191-6643
Denisse RotemBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5030-5919
Dennie FrederickDivision of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA.
Tatyana SharovaDivision of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA.
Benchun MiaoDivision of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA.
Tommy KimDivision of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA.
Greg GydushBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Justin RhoadesBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kevin Y HuangNew York Genome Center, New York, NY, USA.
Nathaniel D OmansNew York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0604-1893
Patrick O BolanMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Andrew H LipskyMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Chelston AngNew York Genome Center, New York, NY, USA.
Murtaza MalbariMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Catherine F SpinelliMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Selena KazanciogluNew York Genome Center, New York, NY, USA.
Alexi M RunnelsNew York Genome Center, New York, NY, USA.
Samantha FennesseyNew York Genome Center, New York, NY, USA.
Christian StolteNew York Genome Center, New York, NY, USA.
Federico GaitiNew York Genome Center, New York, NY, USA.
Giorgio G InghiramiMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5566-0864
Viktor AdalsteinssonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Brian Houck-LoomisNew York Genome Center, New York, NY, USA.
Jennifer IshiiNew York Genome Center, New York, NY, USA.
Jedd D WolchokDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6718-2222
Genevieve BolandDivision of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7522-6173
Nicolas RobineNew York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5698-8183
Nasser K AltorkiMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Dan A LandauNew York Genome Center, New York, NY, USA. dlandau@nygenome.org.ORCID http://orcid.org/0000-0003-2346-9541
Cornell University · USNew York Genome Center · USBroad Institute · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USFred Hutch Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia EvolutionDP2CA239065 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2018 to 2018
$2.5M
Molecular and Translational Oncology ResearchT32CA203702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLENIS, JOHN, GIANNAKAKOU, PARASKEVI · 2017 to 2021
$1.4M
NCI NIH HHS DP2 CA239065NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA203702
6 · The paper itself

Abstract

In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep targeted sequencing paradigm. We reasoned that breadth may supplant depth of sequencing to overcome the barrier of cfDNA abundance. Whole-genome sequencing (WGS) of cfDNA allowed ultra-sensitive detection, capitalizing on the cumulative signal of thousands of somatic mutations observed in solid malignancies, with TF detection sensitivity as low as 10

Indexed as

Biomarkers, TumorCell-Free Nucleic AcidsCirculating Tumor DNADisease-Free SurvivalDNA Copy Number VariationsDNA, NeoplasmFemaleGenome, HumanHigh-Throughput Nucleotide SequencingHumansKaplan-Meier EstimateMaleMutationNeoplasmsTumor BurdenWhole Genome SequencingBiomarkers, TumorCell-Free Nucleic AcidsCirculating Tumor DNADNA, Neoplasm

Identifiers

PMID32483360
PMCPMC8108131
OpenAlexW3028644610

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.