ArticleNature communications2020
The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 80 citations in OpenAlex.
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neural representation of emotional valence in human amygdala and surrounding regions.NeuroImage · 2026Article
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- Phasic dopamine encodes persistent attraction to reward cues.bioRxiv : the preprint server for biology · 2025Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.bioRxiv : the preprint server for biology · 2025Article
- Wanting what hurts: D1 dopamine neuronal stimulation in CeA is sufficient to induce maladaptive attraction.Communications biology · 2025Article
- A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth.bioRxiv : the preprint server for biology · 2025Article
- Exploring the role of the amygdala in Compulsive Sexual Behavior Disorder via a parcellation pipeline based on Recurrence Quantification Analysis.Journal of behavioral addictions · 2025Article
- Article
- The Incentive-Sensitization Theory of Addiction 30 Years On.Annual review of psychology · 2025Review
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- GABA release from central amygdala neurotensin neurons differentially modulates ethanol consumption in male and female mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala.iScience · 2024Article
- GABA Release From Central Amygdala Neurotensin Neurons Differentially Modulates Reward and Consummatory Behavior in Male and Female Mice.bioRxiv : the preprint server for biology · 2023Article
- Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction.PLoS biology · 2023Article
- Separating desire from prediction of outcome value.Trends in cognitive sciences · 2023Review
- Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal.Research square · 2023Article
- Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
How do brain mechanisms create maladaptive attractions? Here intense maladaptive attractions are created in laboratory rats by pairing optogenetic channelrhodopsin (ChR2) stimulation of central nucleus of amygdala (CeA) in rats with encountering either sucrose, cocaine, or a painful shock-delivering object. We find that pairings make the respective rats pursue either sucrose exclusively, or cocaine exclusively, or repeatedly self-inflict shocks. CeA-induced maladaptive attractions, even to the painful shock-rod, recruit mesocorticolimbic incentive-related circuitry. Shock-associated cues also gain positive incentive value and are pursued. Yet the motivational effects of paired CeA stimulation can be reversed to negative valence in a Pavlovian fear learning situation, where CeA ChR2 pairing increases defensive reactions. Finally, CeA ChR2 valence can be switched to neutral by pairing with innocuous stimuli. These results reveal valence plasticity and multiple modes for motivation via mesocorticolimbic circuitry under the control of CeA activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.