ArticleProceedings of the National Academy of Sciences of the United States of America2020
Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Hippo-YAP/TAZ signaling in inner ear development, injury, and regeneration: evidence synthesis and the biomechanical brake hypothesis.Frontiers in cell and developmental biology · 2026Review
- ShH10 viral vector for safe, efficient, and selective transduction of inner ear supporting cells.Developmental biology · 2025Article
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- Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity.bioRxiv : the preprint server for biology · 2025Article
- The Hippo pathway and p27Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chemically defined and dynamic click hydrogels support hair cell differentiation in human inner ear organoids.Stem cell reports · 2025Article
- Long-rangeProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spherical harmonics analysis reveals cell shape-fate relationships in zebrafish lateral line neuromasts.Development (Cambridge, England) · 2024Article
- SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023Review
- Craniofacial Development Is Fine-Tuned by Sox2.Genes · 2023Review
- Generation of innervated cochlear organoid recapitulates early development of auditory unit.Stem cell reports · 2023Article
- Stem cells as potential therapeutics for hearing loss.Frontiers in neuroscience · 2023Review
- Temporal and regulatory dynamics of the inner ear transcriptome during development in mice.Scientific reports · 2022Article
- Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti.NPJ Regenerative medicine · 2022Article
- The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022Review
- Hearing loss: The final frontier of pharmacology.Pharmacology research & perspectives · 2022Review
- In vitro and in vivo models: What have we learnt about inner ear regeneration and treatment for hearing loss?Molecular and cellular neurosciences · 2022Review
- The noncoding genome and hearing loss.Human genetics · 2022Review
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Precise control of organ growth and patterning is executed through a balanced regulation of progenitor self-renewal and differentiation. In the auditory sensory epithelium-the organ of Corti-progenitor cells exit the cell cycle in a coordinated wave between E12.5 and E14.5 before the initiation of sensory receptor cell differentiation, making it a unique system for studying the molecular mechanisms controlling the switch between proliferation and differentiation. Here we identify the Yap/Tead complex as a key regulator of the self-renewal gene network in organ of Corti progenitor cells. We show that Tead transcription factors bind directly to the putative regulatory elements of many stemness- and cell cycle-related genes. We also show that the Tead coactivator protein, Yap, is degraded specifically in the Sox2-positive domain of the cochlear duct, resulting in down-regulation of Tead gene targets. Further, conditional loss of the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.