ArticleProceedings of the National Academy of Sciences of the United States of America2020
Remote nongenetic optical modulation of neuronal activity using fuzzy graphene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Optical Detection of Cellular Signals at Material Interfaces.Advanced healthcare materials · 2026Review
- In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve-on-a-Chip.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Chemically Selective Nanoelectrode Arrays for Real-Time, Parallel Neurotransmitter and Electrical Recording.Small science · 2026Article
- Nanomaterial based photoacoustic interface for non-genetic neuromodulation.Nano futures · 2026Review
- Illuminating the Underlying Mechanism of Intracellular Optoelectronic Modulation Using Silicon Nanowires.ACS nano · 2025Article
- Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nature communications · 2025Article
- Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts.Journal of visualized experiments : JoVE · 2025Article
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- Review
- Parallelized Mechanical Stimulation of Neuronal Calcium Through Cell-Internal Nanomagnetic Forces Provokes Lasting Shifts in the Network Activity State.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nanotechnology-Fortified Manipulation of Cell CaSmall science · 2024Article
- Photothermal Excitation of Neurons Using MXene: Cellular Stress and Phototoxicity Evaluation.Advanced healthcare materials · 2024Article
- High-Precision Photoacoustic Neural Modulation Uses a Non-Thermal Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A silicon diode-based optoelectronic interface for bidirectional neural modulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multifunctional Nanomaterials for Advancing Neural Interfaces: Recording, Stimulation, and Beyond.Accounts of chemical research · 2024Review
- Photoacoustic: A Versatile Nongenetic Method for High-Precision Neuromodulation.Accounts of chemical research · 2024Review
- Augmenting insect olfaction performance through nano-neuromodulation.Nature nanotechnology · 2024Article
- Photocatalytic manipulation of CaScience advances · 2024Article
- Graphene Oxide Nanoparticles and Organoids: A Prospective Advanced Model for Pancreatic Cancer Research.International journal of molecular sciences · 2024Review
- A snapshot review on materials enabled multimodal bioelectronics for neurological and cardiac research.MRS advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to modulate cellular electrophysiology is fundamental to the investigation of development, function, and disease. Currently, there is a need for remote, nongenetic, light-induced control of cellular activity in two-dimensional (2D) and three-dimensional (3D) platforms. Here, we report a breakthrough hybrid nanomaterial for remote, nongenetic, photothermal stimulation of 2D and 3D neural cellular systems. We combine one-dimensional (1D) nanowires (NWs) and 2D graphene flakes grown out-of-plane for highly controlled photothermal stimulation at subcellular precision without the need for genetic modification, with laser energies lower than a hundred nanojoules, one to two orders of magnitude lower than Au-, C-, and Si-based nanomaterials. Photothermal stimulation using NW-templated 3D fuzzy graphene (NT-3DFG) is flexible due to its broadband absorption and does not generate cellular stress. Therefore, it serves as a powerful toolset for studies of cell signaling within and between tissues and can enable therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.