ArticleProceedings of the National Academy of Sciences of the United States of America2020
High-throughput photocapture approach for reaction discovery.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed.
- Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR-Spectroscopy.Angewandte Chemie (International ed. in English) · 2026Review
- Visible Light-Mediated Monofluoromethylation/Acylation of Olefins by Dual Organo-Catalysis.Molecules (Basel, Switzerland) · 2024Article
- Light-Driven Enantioselective Carbene-Catalyzed Radical-Radical Coupling.Angewandte Chemie (International ed. in English) · 2023Article
- Photoredox-Catalyzed Radical-Radical Coupling of Potassium Trifluoroborates with Acyl Azoliums.Synlett : accounts and rapid communications in synthetic organic chemistry · 2023Article
- Parallel multi-droplet platform for reaction kinetics and optimization.Chemical science · 2023Article
- Recent Progress on One-Pot Multisubstrate Screening.Organic process research & development · 2023Review
- Acyl Azolium-Photoredox-Enabled Synthesis ofACS catalysis · 2023Article
- Photoinduced Acylations Via Azolium-Promoted Intermolecular Hydrogen Atom Transfer.Journal of the American Chemical Society · 2023Article
- High-Throughput Platform for Novel Reaction Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization.Chemical reviews · 2022Review
- Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones.Nature communications · 2022Article
- Emerging Applications of Aryl Trifluoromethyl Diazoalkanes and Diazirines in Synthetic Transformations.ACS organic & inorganic Au · 2022Review
- Single-electron Carbene Catalysis in Redox Processes.Trends in chemistry · 2022Article
- NHC and visible light-mediated photoredox co-catalyzed 1,4-sulfonylacylation of 1,3-enynes for tetrasubstituted allenyl ketones.Chemical science · 2022Article
- Suzuki-type cross-coupling of alkyl trifluoroborates with acid fluoride enabled by NHC/photoredox dual catalysis.Chemical science · 2022Article
- Combined Photoredox and Carbene Catalysis for the Synthesis of γ-Aryloxy Ketones.Advanced synthesis & catalysis · 2022Article
- Cooperative NHC/Photoredox Catalyzed Ring-Opening of Aryl Cyclopropanes to 1-Aroyloxylated-3-Acylated Alkanes.Angewandte Chemie (International ed. in English) · 2021Article
- Recent advances in the chemistry and applications of N-heterocyclic carbenes.Nature reviews. Chemistry · 2021Review
- Structure-function relationships in aryl diazirines reveal optimal design features to maximize C-H insertion.Chemical science · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments. The time-intensive nature of reaction analysis presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, we report herein a high-throughput analysis (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and self-assembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) analysis. This analytical platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.