Evidence map›Paper›PMID 32482784›Full record

ArticleThe European respiratory journal2020

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.

Priyadarshini Kachroo, Jarrett D Morrow, Alvin T Kho, Carrie A Vyhlidal, Edwin K Silverman, Scott T Weiss, Kelan G Tantisira, Dawn L DeMeo

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Unravelling the mechanisms driving multimorbidity in COPD to develop holistic approaches to patient-centred care.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  16. Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  17. Article
  18. Frontiers in physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Priyadarshini KachrooChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5807-1333
Jarrett D MorrowChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Alvin T KhoBoston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Carrie A VyhlidalChildren's Mercy Hospital and Clinics, Kansas City, MO, USA.
Edwin K SilvermanChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Scott T WeissChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7196-303X
Kelan G TantisiraChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dawn L DeMeoChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA dawn.demeo@channing.harvard.edu.ORCID 0000-0001-9653-0636
Brigham and Women's Hospital · USBoston Children's Hospital · USChildren's Mercy Hospital · US

Funding

Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2016 to 2020
$12.6M
Systems Biology, Bioinformatics, and BiostatisticsP01HL105339 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2011 to 2015
$12.2M
INTRAUTERINE SMOKE EXPOSURE AND ASTHMA: GENOMIC ORIGINSR01HL097144 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KOBZIK, LESTER, WEISS, SCOTT T · 2009 to 2013
$2.9M
Integrative omics pipeline to identify novel COPD genes and pathwaysK25HL136846 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORROW, JARRETT · 2017 to 2021
$945k
CIGARETTE SMOKE IMPACTS FETAL LUNG DNA METHYLATION AND GENE EXPRESSIONR21HL107927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L, TANTISIRA, KELAN G · 2011 to 2012
$491k
NHLBI NIH HHS K25 HL136846NHLBI NIH HHS P01 HL105339NHLBI NIH HHS P01 HL114501NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL097144NHLBI NIH HHS R21 HL107927
6 · The paper itself

Abstract

COPD likely has developmental origins; however, the underlying molecular mechanisms are not fully identified. Investigation of lung tissue-specific epigenetic modifications such as DNA methylation using network approaches might facilitate insights linking

Indexed as

Phosphatidylinositol 3-KinasesPulmonary Disease, Chronic ObstructiveAdultDNA MethylationEpigenesis, GeneticHumansLungPhosphatidylinositol 3-Kinases

Identifiers

PMID32482784
PMCPMC8087182
OpenAlexW3031826742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.