Evidence map›Paper›PMID 32482664›Full record

ArticleCancer discovery2020

Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis.

Caitlin M O'Connor, Goutham Narla

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Splicing-driven post-translational dysregulation: a new frontier for precision cancer medicine and immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Caitlin M O'ConnorDepartment of Internal Medicine: Genetic Medicine, University of Michigan, Ann Arbor, Michigan. Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-7840-6399
Goutham NarlaDepartment of Internal Medicine: Genetic Medicine, University of Michigan, Ann Arbor, Michigan. Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. gnarla@med.umich.edu.
University of Michigan · US

Funding

Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
Structural and molecular determinants of protein phosphatase 2A in Alzheimer's DiseaseR01CA240993 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NARLA, GOUTHAM, TAYLOR, DEREK JAMES · 2019 to 2023
$3.4M
Small Molecule Activators of PP2A (SMAPs) for Prostate Cancer TherapyR01CA181654 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NARLA, GOUTHAM · 2015 to 2019
$1.9M
NCI NIH HHS R01 CA181654NCI NIH HHS R01 CA240993NCI NIH HHS T32 CA009676
6 · The paper itself

Abstract

Although mutations in

Indexed as

NeoplasmsPhosphoproteinsCarcinogenesisHumansMutationProtein Phosphatase 2RNA SplicingRNA Splicing FactorsPhosphoproteinsPPP2R5A protein, humanProtein Phosphatase 2RNA Splicing FactorsSF3B1 protein, human

Identifiers

PMID32482664
PMCPMC8162994
OpenAlexW3030698159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.