Evidence map›Paper›PMID 32482456›Full record

ArticleTrends in pharmacological sciences2020

Small Molecules Restore Telomeres in Patient Stem Cells.

Kirsten Ann Brenner, Jayakrishnan Nandakumar

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Aging conundrum: A perspective for ovarian aging.Frontiers in endocrinology · 2022
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kirsten Ann BrennerDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Jayakrishnan NandakumarDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: jknanda@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Molecular functions of the shelterin component ACD/TPP1 in somatic stem cells and tissue homeostasisR01AG050509 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEGAN, CATHERINE ELIZABETH, MAILLARD, IVAN · 2015 to 2019
$2.3M
Telomeric Protein Function and RegulationR01GM120094 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NANDAKUMAR, JAYAKRISHNAN · 2016 to 2020
$1.5M
NIA NIH HHS R01 AG050509NIGMS NIH HHS R01 GM120094
6 · The paper itself

Abstract

Genetic defects in telomere maintenance result in stem cell exhaustion and a spectrum of telomere biology diseases. Systemic treatments beyond organ transplantation are lacking for these diseases. Nagpal and colleagues identified small molecules that restore telomere maintenance in patient-derived stem cells, offering a promising therapy for telomere biology diseases.

Indexed as

Dyskeratosis CongenitaTelomeraseHumansRNAStem CellsTelomereRNATelomerasebone marrow failuredyskeratosis congenitaPAPD5PARNtelomeraseTERC

Identifiers

PMID32482456
PMCPMC7384241
OpenAlexW3031294064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.