Evidence map›Paper›PMID 32482020›Full record

ArticleJournal of clinical research in pediatric endocrinology2021

Sirolimus Therapy and Follow-up in a Patient with Severe Congenital Hyperinsulinism Following Subtotal Pancreatectomy

Qiong Chen, Yongxing Chen, Xiaohong Wang, Haihua Yang, Yingxian Zhang, Xiaojing Liu, Yun Yan, Haiyan Wei

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Qiong ChenHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0003-3354-4269
Yongxing ChenHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0002-4131-137X
Xiaohong WangHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0003-2993-9145
Haihua YangHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0002-9414-0762
Yingxian ZhangHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0003-2654-0796
Xiaojing LiuHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0002-9640-8806
Yun YanUniversity of Missouri-Kansas City, Children’s Mercy Hospital, Department of Endocrinology and Diabetes, Missouri, USAORCID 0000-0003-2605-8860
Haiyan WeiHenan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, ChinaORCID 0000-0003-1044-6594
Zhengzhou University · CNChildren's Mercy Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital hyperinsulinism (CHI) is the most common cause of severe, persistent hypoglycemia in neonates and infants. If the patient does not respond to medical treatment the currently available treatment is subtotal pancreatectomy, but some patients still experience severe hypoglycemia after surgery. Sirolimus, a mammalian target of rapamycin inhibitor has recently been reported to be effective in the treatment of insulinoma and CHI patients. Here we report a patient with CHI who had prolonged hypoglycemia after subtotal pancreatectomy. The patient had a heterozygous mutation in

Indexed as

Child, PreschoolCongenital HyperinsulinismFollow-Up StudiesHumansMalePancreatectomyProtein Kinase InhibitorsSeverity of Illness IndexSirolimusSulfonylurea ReceptorsABCC8 protein, humanProtein Kinase InhibitorsSirolimusSulfonylurea ReceptorsABCC8Congenital hyperinsulinismhypoglycemiamTORsirolimus

Identifiers

PMID32482020
PMCPMC7947726
OpenAlexW3030294150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.