Evidence map›Paper›PMID 32481666›Full record

ArticleMolecules (Basel, Switzerland)2020

Functional Expression and Characterization of a Panel of Cobalt and Iron-Dependent Nitrile Hydratases.

Birgit Grill, Maximilian Glänzer, Helmut Schwab, Kerstin Steiner, Daniel Pienaar, Dean Brady, Kai Donsbach, Margit Winkler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Birgit GrillAustrian Center of Industrial Biotechnology GmbH, 8010 Graz, Austria.
Maximilian GlänzerAustrian Center of Industrial Biotechnology GmbH, 8010 Graz, Austria.
Helmut SchwabAustrian Center of Industrial Biotechnology GmbH, 8010 Graz, Austria.
Kerstin SteinerAustrian Center of Industrial Biotechnology GmbH, 8010 Graz, Austria.
Daniel PienaarMolecular Science Institute, School of Chemistry, University of the Witwatersrand, Johannesburg P.O. Wits 2050, South Africa.
Dean BradyMolecular Science Institute, School of Chemistry, University of the Witwatersrand, Johannesburg P.O. Wits 2050, South Africa.ORCID 0000-0002-4815-1030
Kai DonsbachPharmaZell, 83064 Raubling, Germany.
Margit WinklerAustrian Center of Industrial Biotechnology GmbH, 8010 Graz, Austria.ORCID 0000-0002-0754-9704
Austrian Centre of Industrial Biotechnology (Austria) · ATUniversity of the Witwatersrand · ZAInstitute of Molecular Biotechnology · ATPharmaZell (Germany) · DE

Funding

Österreichische Forschungsförderungsgesellschaft 824186
6 · The paper itself

Abstract

Nitrile hydratases (NHase) catalyze the hydration of nitriles to the corresponding amides. We report on the heterologous expression of various nitrile hydratases. Some of these enzymes have been investigated by others and us before, but sixteen target proteins represent novel sequences. Of 21 target sequences, 4 iron and 16 cobalt containing proteins were functionally expressed from

Indexed as

BurkholderiaceaeCatalysisCobaltEscherichia coliHydro-LyasesIronMetalloproteinsMethylobacteriaceaePseudomonasCobaltHydro-LyasesIronMetalloproteinsnitrile hydrataseactive pharmaceutical ingredient.amidebiocatalysismetalloproteinnitrilenitrile hydratase (NHase)non-corrinoid cobaltnon-heme iron

Identifiers

PMID32481666
PMCPMC7321127
OpenAlexW3031497335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.