Evidence map›Paper›PMID 32481601›Full record

ArticlePharmaceutics2020

Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning.

Lara Diego-González, José Crecente-Campo, Matthew John Paul, Mahavir Singh, Rajko Reljic, María José Alonso, África González-Fernández, Rosana Simón-Vázquez

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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  12. New Developments and Insights in the Improvement ofCurrent epidemiology reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Lara Diego-GonzálezInmunología, Centro de Investigaciones Biomédicas, CINBIO, Universidade de Vigo, Campus Universitario Lagoas Marcosende, 36310 Vigo, Spain.
José Crecente-CampoDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus Vida, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), IDIS Research Institute, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0002-8630-5010
Matthew John PaulInstitute for Infection and Immunity, St George's Medical School, London SW17 0RE, UK.
Mahavir SinghLionex GmbH, 38126 Braunschweig, Germany.
Rajko ReljicInstitute for Infection and Immunity, St George's Medical School, London SW17 0RE, UK.
María José AlonsoDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus Vida, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), IDIS Research Institute, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
África González-FernándezInmunología, Centro de Investigaciones Biomédicas, CINBIO, Universidade de Vigo, Campus Universitario Lagoas Marcosende, 36310 Vigo, Spain.ORCID 0000-0002-9226-4825
Rosana Simón-VázquezInmunología, Centro de Investigaciones Biomédicas, CINBIO, Universidade de Vigo, Campus Universitario Lagoas Marcosende, 36310 Vigo, Spain.ORCID 0000-0001-8963-6547
Servicio Gallego de Salud · ESSt George's, University of London · GBUniversidade de Santiago de Compostela · ESLionex (Germany) · DE

Funding

European Regional Development Fund ED431G2019/06Horizon 2020 Framework Programme 643558Xunta de Galicia ED431C 2016/041Xunta de Galicia ED431C 2017/09
6 · The paper itself

Abstract

Tuberculosis (TB) is the leading cause of death from a single infectious microorganism and Bacillus Calmette Guerin (BCG), the only authorized vaccine, does not confer protection against pulmonary TB. Based on the hypothesis that mucosal protection could help to prevent the infection at the site of entrance, the objective of this work was to develop an intranasal vaccine against

Indexed as

10 kDa culture filtrate protein (CFP-10)6 kDa early secretory antigenic target (ESAT-6)antibodiescomplement systemcytokinesImiquimodreactive oxygen species (ROS)Toll-like receptor-7 (TLR-7)vaccination

Identifiers

PMID32481601
PMCPMC7355676
OpenAlexW3030056417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.