Evidence map›Paper›PMID 32481515›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Circulatory Astrocyte and Neuronal EVs as Potential Biomarkers of Neurological Dysfunction in HIV-Infected Subjects and Alcohol/Tobacco Users.

Sunitha Kodidela, Kelli Gerth, Namita Sinha, Asit Kumar, Prashant Kumar, Santosh Kumar

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

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  18. Extracellular Microvesicles Released From Brain Endothelial Cells are Detected in Animal Models Of HIV-1 Signifying Unresolved Inflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sunitha KodidelaCollege of Pharmacy, Department of Pharmaceutical sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA.
Kelli GerthCollege of Pharmacy, Department of Pharmaceutical sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA.
Namita SinhaCollege of Pharmacy, Department of Pharmaceutical sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA.
Asit KumarCollege of Pharmacy, Department of Pharmaceutical sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA.
Prashant KumarDepartment of Pediatrics, University of Tennessee Health Science Center and Le Bonheur Children's Hospital, Memphis, TN 38103, USA.ORCID 0000-0003-1038-6149
Santosh KumarCollege of Pharmacy, Department of Pharmaceutical sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA.ORCID 0000-0001-7846-5674
University of Tennessee Health Science Center · US

Funding

Monocytic and exosomal cytochrome P450s in smoking-mediated HIV-1 pathogenesisR01DA047178 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CORY, THEODORE, KUMAR, SANTOSH · 2018 to 2022
$1.7M
National Institute of Health DA047178NIDA NIH HHS R01 DA047178
6 · The paper itself

Abstract

The diagnosis of neurocognitive disorders associated with HIV infection, alcohol, and tobacco using CSF or neuroimaging are invasive or expensive methods, respectively. Therefore, extracellular vesicles (EVs) can serve as reliable noninvasive markers due to their bidirectional transport of cargo from the brain to the systemic circulation. Hence, our objective was to investigate the expression of astrocytic (GFAP) and neuronal (L1CAM) specific proteins in EVs circulated in the plasma of HIV subjects, with and without a history of alcohol consumption and tobacco smoking. The protein expression of GFAP (

Indexed as

alcoholGFAPHIVL1CAMneurocognitionplasma extracellular vesicles (EVs)/exosomestobacco

Identifiers

PMID32481515
PMCPMC7345258
OpenAlexW3029476117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.