ArticleMedicine2020
Effects of ozone for treating chronically refractory wounds and ulcers: A protocol for systematic review and meta-analysis of randomized clinical trials.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mechanism and clinical application of ozone therapy in treating skin ulcer diseases.Medical gas research · 2026Pooled it
- Ozone as an adjuvant therapy for COVID-19: A systematic review and meta-analysis.International immunopharmacology · 2022Pooled it
- Evaluating the therapeutic efficacy of ozone liquid dressing in healing wounds associated with bullous pemphigoid.Scientific reports · 2025Article
- A clinical study on ozone autohemotherapy for the treatment of acute ischemic stroke.Frontiers in medicine · 2025Article
- Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat's skin.Acta cirurgica brasileira · 2024Article
- Article
- Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis.Frontiers in medicine · 2023Article
- Wearable adjunct ozone and antibiotic therapy system for treatment of Gram-negative dermal bacterial infection.Scientific reports · 2022Article
- Evaluation of a New Tubular Finger Oxygen-Enriched Oil Inside-Coated Dressing Device in Pediatric Patients Undergoing Distal Hypospadias Repair: A Prospective Randomized Clinical Trial Part II.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of chronically refractory wounds and ulcers is growing rapidly. However, the treatment options are not completely effective. Ozone has been demonstrated as being useful in promoting wound healing as well as adverse events in individual studies. Consequently, it is necessary to conduct a meta-analysis of high-quality trials to find out whether ozone therapy is effective and safe in these chronic wounds.
methodsWe will search the Cochrane Library, PubMed, the Web of Science, Embase, CBM, and the Chinese Clinical Registry website without restriction on language, date, or study setting. Randomized controlled trials of ozone therapy for chronical wounds or ulcers will be retrieved in diverse databases from inception to May 2020. The primary outcome of the meta-analysis is the proportion of participants with completely healed wounds; time to achieve complete ulcer healing; change in wound size. The secondary outcomes include the incidence of adverse events, amputation, quality of life, length of hospital stay, and cost. Two reviewers will adopt the Cochrane Collaboration's risk of bias tool to assess the randomized controlled trials and all relevant data will be analyzed by utilizing the Review Manager software V5.3.0.
resultsThis study will offer a high-quality synthesis of the effectiveness and safety of ozone for treating chronically refractory wounds and ulcers.
conclusionThis systematic review and meta-analysis will find out the available evidence to assess whether ozone therapy is beneficial to wound healing and side effects, producing evidence reference for clinical practice on the treatment of wound care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.