ArticleJournal of musculoskeletal & neuronal interactions2020
Expression of miR-204 in patients with osteoarthritis and its damage to chondrocytes.
Article in Journal of musculoskeletal & neuronal interactions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules.Biomolecules · 2026Review
- miR-655-3p is a highly accurate diagnostic biomarker for primary osteoarthritis and alleviates joint inflammation by targeting TLR4.Acta orthopaedica et traumatologica turcica · 2026Article
- Diagnostic value and role in promoting fracture healing of deregulated circulating miR-204 in patients with osteoporotic fractures.Journal of orthopaedic surgery and research · 2026Article
- LncRNA LINC00704 drives cancer stemness and malignant properties in oral squamous cell carcinomas by sponging miR-204.Journal of dental sciences · 2025Article
- CRNDE alleviates IL-1β-induced chondrocyte damage by modulating miR-31/NF-κB pathway.Journal of orthopaedic surgery and research · 2024Article
- MiR-217 Regulates SIRT1 Expression and Promotes Inflammatory and Apoptotic Responses in Osteoarthritis.Genes · 2023Article
- Article
- Integrative Analysis of the Expression of microRNA, Long Noncoding RNA, and mRNA in Osteoarthritis and Construction of a Competing Endogenous Network.Biochemical genetics · 2022Article
- Knockdown of long noncoding RNA HOTAIR inhibits osteoarthritis chondrocyte injury by miR-107/CXCL12 axis.Journal of orthopaedic surgery and research · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the expression of miR-204 in patients with Osteoarthritis (OA) and its effect on chondrocytes.
methodsCartilage tissues of patients with OA, and normal cartilage tissues of patients receiving emergent traumatic amputation were collected. Polymerase chain reaction (PCR) was used to quantify the expressions of miRNAs. Chondrocytes of patients with OA were isolated, cultured, and transfected with miR-204 mimics or miR-204 inhibitor, and cell models of over-expression and knockdown of miR-204 were constructed. MTT assay, clone formation test, trypan blue staining, and TdT-mediated dUTP Nick-End Labeling (TUNEL) staining were used to detect the effect of overexpression or knockdown of miR-204 on viability, proliferation, survival rate and apoptosis of chondrocytes.
resultsmiR-204 expression increased significantly in cartilage tissue of patients with OA. Results of MTT assay, clone formation test, and trypan blue staining showed that the over-expression of miR-204 inhibited the viability, proliferation, and survival rate, as well as promoted the apoptosis of chondrocytes. Whereas the knockdown of miR-204 improved the viability, proliferation, and survival rate of chondrocytes.
conclusionThe expression of miR-204 increased significantly in patients with OA and played a damaging role in chondrocytes. The knockdown of miR-204 may provide new approaches for clinical treatment of OA.
Indexed as
Identifiers
32481242PMC7288379W3029074449What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.