Observational studyThe Journal of clinical endocrinology and metabolism2020
Associations of Per- and Polyfluoroalkyl Substances (PFAS) With Glucose Tolerance During Pregnancy in Project Viva.
Observational study in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.Environmental health : a global access science source · 2022Pooled it
- Per- and Polyfluoroalkyl Substances (PFAS) in Integrated Crop-Livestock Systems: Environmental Exposure and Human Health Risks.International journal of environmental research and public health · 2021Pooled it
- PFAS Exposure and Metabolic Disorders: Mechanistic Insights into Lipid and Glucose Homeostasis.Biomolecules · 2026Review
- Per- and Polyfluoroalkyl Substances During Pregnancy and Gestational Diabetes: The Environmental Influences on Child Health Outcomes (ECHO) Cohort.Diabetes care · 2026Article
- PPARs, L-FABP mediate the association between Per- and polyfluoroalkyl substances and gestational diabetes: a nested case-control study.Scientific reports · 2026Article
- Maternal per- and polyfluoroalkyl substances exposure and the co-occurrence of gestational diabetes mellitus and preeclampsia/eclampsia: a nested case-control study.Frontiers in public health · 2026Article
- Prenatal PFAS exposure and outcomes related to maternal gut microbiome composition in later pregnancy.Environmental research · 2025Article
- Per- and Polyfluoroalkyl Substances and Outcomes Related to Metabolic Syndrome: A Review of the Literature and Current Recommendations for Clinicians.American journal of lifestyle medicine · 2025Review
- Review
- Associations of per- and polyfluoroalkyl substances with maternal metabolic and inflammatory biomarkers in early-to-mid-pregnancy.Environmental research · 2024Article
- PFAS concentrations in early and mid-pregnancy and risk of gestational diabetes mellitus in a nested case-control study within the ethnically and racially diverse PETALS cohort.BMC pregnancy and childbirth · 2023Article
- Gestational diabetes mellitus in relation to serum per- and polyfluoroalkyl substances: A scoping review to evaluate the need for a new systematic review.F1000Research · 2023Article
- Perfluorinated compounds in adults and their association with fasting glucose and incident diabetes: a prospective cohort study.Environmental health : a global access science source · 2022Article
- Maternal urinary organophosphate ester metabolite concentrations and glucose tolerance during pregnancy: The HOME Study.International journal of hygiene and environmental health · 2022Article
- Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects.International journal of environmental research and public health · 2021Review
- Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review.Journal of xenobiotics · 2021Article
- Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.Endocrine reviews · 2021Review
- A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus.Environmental health : a global access science source · 2021Review
- Persistent organic pollutants and maternal glycemic outcomes in a diverse pregnancy cohort of overweight women.Environmental research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
contextPer- and polyfluoroalkyl substances (PFAS) exposure may alter glucose homeostasis. Research on PFAS exposure and glucose tolerance during pregnancy is limited.
objectiveThe objective of this work is to estimate associations between first-trimester plasma PFAS concentrations and glucose tolerance assessed in late second pregnancy trimester. DESIGN, SETTING, PARTICIPANTS, AND
main outcome measuresPregnant women (n = 1540) enrolled in Project Viva in 1999 to 2002 provided first-trimester plasma samples analyzed for 8 PFAS. At approximately 28 weeks' gestation, women completed 1-hour nonfasting, 50-g oral glucose challenge tests (GCTs); if abnormal, women completed subsequent 3-hour oral glucose tolerance tests (OGTTs) to screen for gestational diabetes mellitus (GDM). We assessed both continuous GCT glucose levels and 4 categories of glucose tolerance (normal glycemia [reference], isolated hyperglycemia, impaired glucose tolerance, GDM). We used multinomial logistic regression to estimate associations of PFAS with glucose tolerance categories. We used multivariable linear regression and Bayesian kernel machine regression (BKMR) to assess individual and joint effects of PFAS on continuous GCT glucose levels, respectively. We evaluated effect modification by maternal age and race/ethnicity.
resultsPFAS were not associated with glucose tolerance categories. In BKMR analyses, we observed a positive association between ln-perfluorooctane sulfonate (PFOS) and glucose levels (Δ25th to 75th percentile: 6.2 mg/dL, 95% CI, 1.1-11.3) and an inverse-U shaped association between 2-(N-perfluorooctane sulfonamide) acetate and glucose levels. Individual linear regression results were similar. We found suggestive evidence that associations varied by age and racial/ethnic group.
conclusionCertain PFAS may alter glucose homeostasis during pregnancy, but may not be associated with overt GDM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.