ArticleInternational journal of surgery case reports2020
Atraumatic splenic rupture in a patient treated with apixaban: A case report.
Article in International journal of surgery case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Spontaneous spleen rupture due to rivaroxaban: a case report.International journal of surgery case reports · 2026Article
- Analysis of the clinical characteristics of direct oral anticoagulants-associated atraumatic splenic rupture.Frontiers in pharmacology · 2026Article
- Management of spontaneous atraumatic splenic rupture in the setting of anticoagulation: case report and literature review.Journal of surgical case reports · 2025Article
- Differences in Management and Outcomes in Atraumatic Splenic Rupture Compared to Traumatic Injury Following Blunt Abdominal Trauma.Journal of clinical medicine · 2024Article
- Article
- Atraumatic splenic rupture in a patient treated with rivaroxaban: A case report and a narrative review.Clinical case reports · 2022Article
- Atraumatic Splenic Rupture on Direct Oral Anticoagulation.Journal of community hospital internal medicine perspectives · 2022Article
- A case report of atraumatic splenic rupture after coronary stenting and dual antiplatelet therapy: Causality or relationship?International journal of surgery case reports · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSplenic rupture is often seen in the context of significant trauma. Atraumatic ruptures are described in the context of malignancy, inflammation or infection directly affecting the spleen. Splenic ruptures occurring in patients taking apixaban, a factor Xa inhibitor, are challenging due to the scarcity of a direct reversal agent. PRESENTATION OF CASE: A 66 year old male presented with syncope and back pain and was found to be haemodynamically unstable and tender in the left upper quadrant. There was no preceding trauma. He has a background of extensive major arterial reconstruction and was taking apixaban for atrial fibrillation. A diagnosis of splenic rupture was confirmed on cross sectional imaging. A laparotomy and splenectomy was necessitated as salvage therapy following splenic artery embolisation. He recovered well and was discharged home 6 days after laparotomy.
conclusionDefinitive intervention is required for the management of splenic ruptures. A high level of clinical suspicion should be maintained in patients taking direct oral anticoagulants presenting with haemodynamic instability. Open splenectomy remains the most definitive option for treatment of atraumatic rupture in anticoagulated patients.
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