Evidence map›Paper›PMID 32480242›Full record

ArticleJournal of neuroimmunology2020

LGI1-antibody associated epilepsy successfully treated in the outpatient setting.

R Uribe-San-Martín, E Ciampi, R Santibañez, S R Irani, A Márquez, J P Cruz, B Soler, M C Miranda, M Henríquez, C Cárcamo

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuroimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Seizures in steroid-responsive encephalopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

R Uribe-San-MartínNeurology Service, Hospital Dr. Sótero del Río, Santiago, Chile; Neurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: ruribe@med.puc.cl.
E CiampiNeurology Service, Hospital Dr. Sótero del Río, Santiago, Chile; Neurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
R SantibañezNeurology Service, Hospital Dr. Sótero del Río, Santiago, Chile; Neurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
S R IraniOxford Autoimmune Neurology Group, Nuffield Department of Clinical. Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford, UK; Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
A MárquezNeurology Service, Hospital Dr. Sótero del Río, Santiago, Chile; Neurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
J P CruzNeuroradiology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
B SolerNeurology Service, Hospital Dr. Sótero del Río, Santiago, Chile; Neurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
M C MirandaNeurology Service, Hospital Dr. Sótero del Río, Santiago, Chile; Neurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
M HenríquezClinical Laboratories Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
C CárcamoNeurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
Complejo Asistencial Sótero del Río · CLPontificia Universidad Católica de Chile · CLUniversity of Oxford · GB

Funding

Wellcome Trust 104079/Z/14/Z
6 · The paper itself

Abstract

We report six patients with anti-LGI1 associated epilepsy. Two patients presented with new-onset generalized tonic-clonic seizures, four developed faciobrachial dystonic seizures and two piloerection. All patients had significant cognitive complaints at the time of diagnosis. All patients described seizure reduction during the first week of carbamazepine, and seizure freedom was obtained at a median of 13 days (range 7-22), sustained after the initiation of immunosuppression. Median time from symptom onset to carbamazepine initiation was 164 days (range 38-206 days). We discuss the particular seizure response to sodium channel blocking antiepileptic drugs, alone or associated with immunosuppression in this antibody mediated seizures.

Indexed as

AdultAgedAmbulatory CareAnticonvulsantsAutoantibodiesCarbamazepineEpilepsyFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedOutpatientsProspective StudiesTreatment OutcomeAnticonvulsantsAutoantibodiesCarbamazepineIntracellular Signaling Peptides and ProteinsLGI1 protein, humanAntibody mediated seizuresAutoimmune epilepsyCarbamazepineLeucine-rich glioma-inactivated 1 (LGI1) autoantibodiesNeuroimmunology

Identifiers

PMID32480242
PMCPMC7339132
OpenAlexW3027804197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.