Evidence map›Paper›PMID 32480160›Full record

ArticleEcotoxicology and environmental safety2020

Prenatal exposure to ambient air multi-pollutants significantly impairs intrauterine fetal development trajectory.

Xiaowen Shao, Haoxiang Cheng, Jonathan Zhou, Jushan Zhang, Yujie Zhu, Chun Yang, Antonio Di Narzo, Jing Yu, Yuan Shen, Yuanyuan Li and 5 more

Abstract read
In one paragraph

Article in Ecotoxicology and environmental safety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaowen ShaoDepartment of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Haoxiang ChengDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jonathan ZhouDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jushan ZhangDepartment of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yujie ZhuDepartment of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Chun YangDepartment of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Antonio Di NarzoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jing YuDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yuan ShenDepartment of Psychiatry, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yuanyuan LiKey Laboratory of Environment and Health, Ministry of Education & Ministry of Ecology and Environment, And State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Shunqing XuKey Laboratory of Environment and Health, Ministry of Education & Ministry of Ecology and Environment, And State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhongyang ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jia ChenDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jiajing ChengDepartment of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. Electronic address: chengjiajing1963@163.com.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China; College of Environmental Science and Engineering, Tongji University, Shanghai, China. Electronic address: ke.hao@mssm.edu.

Funding

Placental Functional Networks Linking Developmental Pesticide Exposure and Offspring NeurodevelopmentR01ES029212 · NIEHS · EMORY UNIVERSITY · PI CAUDLE, WILLIAM MICHAEL, CHEN, JIA · 2018 to 2022
$2.7M
NIEHS NIH HHS R01 ES029212
6 · The paper itself

Abstract

backgroundImpaired in utero fetal growth trajectory may have long term health consequences of the newborns and increase risk of adulthood metabolic diseases. Prenatal exposure to air pollution has been linked to fetal development restriction; however, the impact of exposure to ambient air pollutants on the entire course of intrauterine fetal development has not been comprehensively investigated.

methodsDuring 2015-2018, two cohorts of mother-infant dyads (N = 678 and 227) were recruited in Shanghai China, from which three categories of data were systematically collected: (1) daily exposure to six air pollutants during pregnancy, (2) fetal biometry in the 2nd (gestational week 24, [GW24]) and 3rd trimester (GW36), and (3) neonatal outcomes at birth. We investigated the impact of prenatal exposure to air pollutant mixture on the trajectory of fetal development during the course of gestation, adjusting for a broad set of potential confounds.

resultsPrenatal exposure to PM

conclusionsTo our knowledge, for the first time, we demonstrated the impact of prenatal exposure to ambient air pollutants on the course of intrauterine fetal development. The altered growth trajectory and rapid catch-up growth in associated with high prenatal exposure may lead to long-term predisposition for adulthood metabolic disorders.

Indexed as

AdultAir PollutantsChinaCohort StudiesFemaleFetal DevelopmentGestational AgeHumansInfant, NewbornMaternal ExposureParticulate MatterPregnancyAir PollutantsParticulate MatterBirth outcomeFetal biometryFetal development trajectoryPrenatal ambient air pollutant exposure

Identifiers

PMID32480160
PMCPMC7363555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.