Evidence map›Paper›PMID 32480042›Full record

ArticleMolecular metabolism2020

Lack of Gα

Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Molecular metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. GαInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Targeting GαBasic research in cardiology · 2024
    Article
  7. Protective effects of GαNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Veronika LeissDepartment of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacoge-nomics and Drug Research, University of Tübingen, 72074, Tübingen, Germany.
Annika SchönsiegelDepartment of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacoge-nomics and Drug Research, University of Tübingen, 72074, Tübingen, Germany.
Thorsten GnadInstitute of Pharmacology and Toxicology, University of Bonn, 53127, Bonn, Germany.
Johannes KernerDepartment of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacoge-nomics and Drug Research, University of Tübingen, 72074, Tübingen, Germany.
Jyotsna KaurDepartment of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacoge-nomics and Drug Research, University of Tübingen, 72074, Tübingen, Germany.
Tina SartoriusDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tuebingen, Tuebingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen (IDM), Tuebingen, Germany.
Jürgen MachannGerman Center for Diabetes Research (DZD), Neuherberg, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen (IDM), Tuebingen, Germany; Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University of Tuebingen, Germany.
Fritz SchickSection on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University of Tuebingen, Germany.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA; Institute of Biomedical Research (BIOMED), Catholic University of Argentina, Buenos Aires, Argentina.
Hans-Ulrich HäringDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tuebingen, Tuebingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen (IDM), Tuebingen, Germany.
Alexander PfeiferInstitute of Pharmacology and Toxicology, University of Bonn, 53127, Bonn, Germany.
Bernd NürnbergDepartment of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacoge-nomics and Drug Research, University of Tübingen, 72074, Tübingen, Germany. Electronic address: bernd.nuernberg@uni-tuebingen.de.
University of Tübingen · DEUniversity of Bonn · DEDeutsches Diabetes-Zentrum e.V. · DEGerman Center for Diabetes Research · DEHeinrich Heine University Düsseldorf · DEPontificia Universidad Católica Argentina · AR

Funding

Transmembrane Signaling MechanismsZ01ES101643 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$5.1M
Intramural NIH HHS Z01 ES101643
6 · The paper itself

Abstract

objectivesTypically, obesity results from an inappropriate balance between energy uptake from nutrient consumption and burning of calories, which leads to a pathological increase in fat mass. Obesity is a major cause of insulin resistance and diabetes. Inhibitory G proteins (Gα

methodsBy using AdipoqCreER

resultsAn adipocyte-specific deficiency of Gα

conclusionWe conclude that adipocyte Gα

Indexed as

Adipocytes, BrownAdipocytes, WhiteAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsDiet, High-FatEnergy MetabolismGlucoseGlucose IntoleranceGTP-Binding Protein alpha Subunit, Gi2GTP-Binding Protein alpha Subunits, Gi-GoInsulinInsulin ResistanceLipolysisMaleGlucoseGTP-Binding Protein alpha Subunit, Gi2GTP-Binding Protein alpha Subunits, Gi-GoInsulinAdipocytesbrown adipose tissueGnai2G proteinsHigh fat dietInsulinObesityWhite adipose tissue

Identifiers

PMID32480042
PMCPMC7306590
OpenAlexW3030299842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.