Observational studyThe Journal of infection2020
A clinical risk score to identify patients with COVID-19 at high risk of critical care admission or death: An observational cohort study.
Observational study in The Journal of infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 13 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Risk of COVID-19 death for people with a pre-existing cancer diagnosis prior to COVID-19-vaccination: A systematic review and meta-analysis.International journal of cancer · 2024Pooled it
- The effects of hypertension on the prognosis of coronavirus disease 2019: a systematic review and meta-analysis on the interactions with age and antihypertensive treatment.Journal of hypertension · 2022Pooled it
- Are patients with cancer at higher risk of COVID-19-related death? A systematic review and critical appraisal of the early evidence.Journal of cancer policy · 2022Pooled it
- Significant association between ischemic heart disease and elevated risk for COVID-19 mortality: A meta-analysis.The American journal of emergency medicine · 2022Pooled it
- Rapid Evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality.Acta anaesthesiologica Scandinavica · 2022Pooled it
- Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis.Journal of racial and ethnic health disparities · 2021Pooled it
- Pooled it
- Is Cancer an Independent Risk Factor for Fatal Outcomes of Coronavirus Disease 2019 Patients?Archives of medical research · 2021Pooled it
- Pre-existing health conditions and severe COVID-19 outcomes: an umbrella review approach and meta-analysis of global evidence.BMC medicine · 2021Pooled it
- Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID-19: a systematic review and meta-analysis.Medical microbiology and immunology · 2021Pooled it
- Cumulative Evidence for the Association of Thrombosis and the Prognosis of COVID-19: Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Effect of immunosuppressive drugs in immune-mediated inflammatory disease during the coronavirus pandemic.Dermatologic therapy · 2020Pooled it
- Pooled it
- Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial.The Lancet. Respiratory medicine · 2023Trial
- Evaluating the Effect of a COVID-19 Predictive Model to Facilitate Discharge: A Randomized Controlled Trial.Applied clinical informatics · 2022Trial
- Prognostic model to identify and quantify risk factors for mortality among hospitalised patients with COVID-19 in the USA.BMJ open · 2021Trial
- ACCREDIT: Validation of clinical score for progression of COVID-19 while hospitalized.Global epidemiology · 2025Article
- Classification of the ICU Admission for COVID-19 Patients with Transfer Learning Models Using Chest X-Ray Images.Diagnostics (Basel, Switzerland) · 2025Article
- COVID-19 Readmission Is Highest Among Refugees in Denmark.International journal of environmental research and public health · 2025Article
- The Role of Sex and Gender in Precision Emergency Medicine: A Scoping Review and Proposed Hierarchy.Clinical therapeutics · 2024Article
80 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
Abstract
backgroundThe COVID-19 pandemic continues to escalate. There is urgent need to stratify patients. Understanding risk of deterioration will assist in admission and discharge decisions, and help selection for clinical studies to indicate where risk of therapy-related complications is justified.
methodsAn observational cohort of patients acutely admitted to two London hospitals with COVID-19 and positive SARS-CoV-2 swab results was assessed. Demographic details, clinical data, comorbidities, blood parameters and chest radiograph severity scores were collected from electronic health records. Endpoints assessed were critical care admission and death. A risk score was developed to predict outcomes.
findingsAnalyses included 1,157 patients. Older age, male sex, comorbidities, respiratory rate, oxygenation, radiographic severity, higher neutrophils, higher CRP and lower albumin at presentation predicted critical care admission and mortality. Non-white ethnicity predicted critical care admission but not death. Social deprivation was not predictive of outcome. A risk score was developed incorporating twelve characteristics: age>40, male, non-white ethnicity, oxygen saturations<93%, radiological severity score>3, neutrophil count>8.0 x10
interpretationOur study identified predictors of critical care admission and death in people admitted to hospital with COVID-19. These predictors were incorporated into a risk score that will inform clinical care and stratify patients for clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.