Evidence map›Paper›PMID 32479758›Full record

ReviewThe Journal of allergy and clinical immunology2020

SARS-CoV-2 antibody testing-questions to be asked.

Mustafa K Özçürümez, Andreas Ambrosch, Oliver Frey, Verena Haselmann, Stefan Holdenrieder, Michael Kiehntopf, Michael Neumaier, Michael Walter, Folker Wenzel, Roman Wölfel and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
2.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Immunoglobulin (Ig)A seropositivity against SARS-CoV-2 in healthcare workers in Israel, 4 April to 13 July 2020: an observational study.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
    Observational
  19. Rapid, Cheap, and Effective COVID-19 Diagnostics for Africa.Diagnostics (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 1 country.

Mustafa K ÖzçürümezDepartment of Laboratory Medicine of the Medical Clinic at the University Medical Center Knappschaftskrankenhaus Bochum, Ruhr University, Bochum, Germany. Electronic address: mustafa@ozcurumez.de.
Andreas AmbroschInstitute of Laboratory Medicine, Microbiology and Hygiene, Barmherzige Brüder Hospital, Regensburg, Germany.
Oliver FreyInstitute of Laboratory Medicine, Brandenburg Medical School, Brandenburg an der Havel, Germany; Institute of Medical Diagnostics, Berlin, Germany.
Verena HaselmannInstitute of Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
Stefan HoldenriederInstitute for Laboratory Medicine, German Heart Centre, Technical University Munich, Munich, Germany.
Michael KiehntopfDepartment of Clinical Chemistry and Laboratory Medicine, Jena University Hospital, Jena, Germany.
Michael NeumaierInstitute of Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
Michael WalterInstitute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, Rostock, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité University Medical Center, Berlin, Germany.
Folker WenzelFaculty of Medical and Life Sciences, Hochschule Furtwangen, Furtwangen, Germany.
Roman WölfelBundeswehr Institute of Microbiology, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Harald RenzInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany.
COVID-19 Task Force of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL)
CS Diagnostics · DEDeutsches Herzzentrum München · DEFurtwangen University · DEGerman Center for Lung Research · DEJena University Hospital · DEKrankenhaus Barmherzige Brüder · DEUniversität der Bundeswehr München · DEUniversitätsklinikum Knappschaftskrankenhaus Bochum · DEUniversity Hospital Heidelberg · DEUniversity Medical Centre Mannheim · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 infection and development of coronavirus disease 2019 presents a major health care challenge of global dimensions. Laboratory diagnostics of infected patients, and the assessment of immunity against severe acute respiratory syndrome coronavirus 2, presents a major cornerstone in handling the pandemic. Currently, there is an increase in demand for antibody testing and a large number of tests are already marketed or are in the late stage of development. However, the interpretation of test results depends on many variables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protectivity, the diagnostic value of antibodies of different isotypes, and the use of antibody testing in identification of acutely ill patients or in epidemiological settings. In this article, the recently established COVID-19 Task Force of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) addresses these issues on the basis of currently available data sets in this rapidly moving field.

Indexed as

Antibodies, ViralBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingHumansImmunologic TestsPandemicsPneumonia, ViralSARS-CoV-2Serologic TestsAntibodies, ViralAntibody responseCOVID-19diagnostic pathwayexternal quality assuranceimmunityimmunoassayneutralization assayrespiratory tract infectionsserologic testssevere acute respiratory syndrome coronavirus 2

Identifiers

PMID32479758
PMCPMC7256507
OpenAlexW3028715179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.