Evidence map›Paper›PMID 32479639›Full record

ArticleNucleic acids research2020

TopMatch-web: pairwise matching of large assemblies of protein and nucleic acid chains in 3D.

Markus Wiederstein, Manfred J Sippl

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  13. Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB.Acta crystallographica. Section F, Structural biology communications · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Markus WiedersteinParis-Lodron-University of Salzburg, Department of Biosciences, Hellbrunner Str. 34, 5020 Salzburg, Austria.
Manfred J SipplParis-Lodron-University of Salzburg, Department of Biosciences, Hellbrunner Str. 34, 5020 Salzburg, Austria.
University of Salzburg · AT

Funding

Compressive Structural BioInformatics: High Efficiency 3D Structure CompressionU01CA198942 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSE, PETER W · 2015 to 2017
$1.6M
NCI NIH HHS U01 CA198942
6 · The paper itself

Abstract

Frequently, the complete functional units of biological molecules are assemblies of protein and nucleic acid chains. Stunning examples are the complex structures of ribosomes. Here, we present TopMatch-web, a computational tool for the study of the three-dimensional structure, function and evolution of such molecules. The unique feature of TopMatch is its ability to match the protein as well as nucleic acid chains of complete molecular assemblies simultaneously. The resulting structural alignments are visualized instantly using the high-performance molecular viewer NGL. We use the mitochondrial ribosomes of human and yeast as an example to demonstrate the capabilities of TopMatch-web. The service responds immediately, enabling the interactive study of many pairwise alignments of large molecular assemblies in a single session. TopMatch-web is freely accessible at https://topmatch.services.came.sbg.ac.at.

Indexed as

Nucleic Acid ConformationProtein ConformationSoftwareHumansInternetModels, MolecularProteinsRibosomal ProteinsRibosomesRNA, RibosomalProteinsRibosomal ProteinsRNA, Ribosomal

Identifiers

PMID32479639
PMCPMC7319569
OpenAlexW3032347096

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.