ArticlePloS one2020
Characterization of native Escherichia coli populations from bovine vagina of healthy heifers and cows with postpartum uterine disease.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Characterization of the vaginal bacterial microbiota of sheep exhibiting abortion or repeat breeder syndrome.Veterinary and animal science · 2026Article
- Development of Mucoadhesive Nanofiber as an Alternate Therapeutic Regimen for Subclinical Endometritis in Cattle.Turkish journal of pharmaceutical sciences · 2026Article
- Characterization of biofilm and exopolysaccharide production in Bacillus strains isolated from the bovine uterus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Reproductive Tract Microbial Transitions from Late Gestation to Early Postpartum Using 16S rRNA Metagenetic Profiling in First-Pregnancy Heifers.International journal of molecular sciences · 2024Article
- Two Novel Bacteriophage Species Against Hybrid Intestinal PathogenicPHAGE (New Rochelle, N.Y.) · 2024Article
- Antimicrobial efficiency of bromhexine hydrochloride against endometritis-causing Escherichia coli and Trueperella pyogenes in bovines.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Uterine Disease in Dairy Cows: A Comprehensive Review Highlighting New Research Areas.Veterinary sciences · 2024Review
- Population characteristics of pathogenicFrontiers in microbiology · 2024Article
- Bovine reproductive tract and microbiome dynamics: current knowledge, challenges, and its potential to enhance fertility in dairy cows.Frontiers in microbiomes · 2024Review
- Current Insights in the Repeat Breeder Cow Syndrome.Animals : an open access journal from MDPI · 2023Review
- Causes of Mortality of Dairy Cattle Diagnosed by Complete Necropsy.Animals : an open access journal from MDPI · 2022Article
- Isolation and Molecular Characterization of Two Novel Lytic Bacteriophages for the Biocontrol ofPharmaceutics · 2022Article
- Adaptive sampling during sequencing reveals the origins of the bovine reproductive tract microbiome across reproductive stages and sexes.Scientific reports · 2022Article
- Relationship between Escherichia coli virulence factors, notably kpsMTII, and symptoms of clinical metritis and endometritis in dairy cows.The Journal of veterinary medical science · 2022Article
- Article
- Antibiotic resistance and phylogenetic profiling ofCurrent research in microbial sciences · 2022Article
- Predisposing factors, diagnostic and therapeutic aspects of persistent endometritis in postpartum cows.The Journal of reproduction and development · 2021Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though Escherichia coli are common bacteria of the bovine vaginal microbiota, they represent an important pathogen that causes diseases in the reproductive tract and subfertility. However, the actual endometrial virulence profile of E. coli is poorly understood. The present study aims to characterize the phylogenetic structure and virulence potential of native vaginal populations of E. coli from healthy heifers (H), and cows with postpartum uterine diseases (PUD), such as metritis/endometritis (MT) or repeat breeder cows (RB). To this end, the virulence repertoire of 97 E. coli isolates was genotypically and phenotypically assessed. Most of them were assigned to phylogenetic group A (74%), followed by B1 (17%) and D (9%); RB strains were significantly (p < 0.05) more represented by B1. Seven of the 15 evaluated virulence genes (VFG) were detected and the most prevalent were fimH (87%), agn43 (41%) and csgA (35%); while traT (27%), fyuA (11%), hlyA (5%) and kpsMT II (5%) were observed in a lower proportion. Particularly, fyuA was significantly higher (p < 0.05) in MT cows whereas csgA showed the same behavior in PUD animals (p < 0.05). When comparing H and PUD strains, these last ones were associated to positive expression of biofilm, fimbriae curli/cellulose and motility; yet RB strains did not show motility. Vaginal B1 E. coli populations, that possess VFG (fyuA and csgA) as well as the expression of motility, curli fimbriae/cellulose and biofilm, may represent risk factors for endometrial disorders; specifically, those that also, have kpsMT II may have a pathogenic potential for causing the RB syndrome. Future research focusing on the detection of these strains in the vaginal microbiota of cows with postpartum uterine diseases should be done since the control of their presence in vagina could reduce the risk that they access the uterus during the postpartum period.
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