Evidence map›Paper›PMID 32479509›Full record

Observational studyPloS one2020

Plasma glucocorticogenic activity, race/ethnicity and alcohol intake among San Francisco Bay Area women.

Phum Tachachartvanich, Sylvia S Sanchez, Scarlett L Gomez, Esther M John, Martyn T Smith, Laura Fejerman

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Phum TachachartvanichDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, United States of America.ORCID 0000-0002-9783-6482
Sylvia S SanchezDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, United States of America.ORCID 0000-0002-3649-778X
Scarlett L GomezCancer Prevention Institute of California, Fremont, CA, United States of America.
Esther M JohnCancer Prevention Institute of California, Fremont, CA, United States of America.
Martyn T SmithDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, United States of America.
Laura FejermanDivision of General Internal Medicine and Institute of Human Genetics, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, United States of America.
University of California, Berkeley · USCancer Prevention Institute of California · USUniversity of California, San Francisco · US

Funding

Exposomic approach to understand the effect of immigration and genetic ancestry on breast cancer risk in U.S. LatinasR21CA210023 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEJERMAN, LAURA · 2016 to 2017
$386k
BREAST CANCER RISK FACTORS IN HISPANIC WOMENR01CA063446 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M · 1995 to 1998
–
NCI NIH HHS R01 CA063446NCI NIH HHS R21 CA210023
6 · The paper itself

Abstract

Racial and ethnic minorities are at higher risk for a variety of diseases. While sociodemographic and lifestyle factors contribute to racial/ethnic health disparities, the biological processes underlying these associations remain poorly understood. Stress and its biological consequences through the glucocorticoid receptor (GR) have been hypothesized to mediate adverse disease outcomes. In fasting morning samples of 503 control women from the San Francisco Bay Area Breast Cancer Study, we used a sensitive Chemical-Activated LUciferase gene eXpression (CALUX) assay to examine the association of sociodemographic and lifestyle factors with plasma glucocorticogenic (G) activity in three racial/ethnic groups. The G activity is a sensitive measure that reflects biological activity of total plasma glucocorticoids including cortisol and glucocorticoid-like compounds. Associations between G activity and sociodemographic and lifestyle factors were examined using multivariable linear regression models. Latina and non-Latina Black (NLB) women had 9% (P = 0.053) and 14% (P = 0.008) lower morning G activity than non-Latina White (NLW) women, respectively. Additionally, we replicated a previously reported association between G activity and alcohol intake (women who drank >10gms had 19% higher G activity than non-drinkers, P = 0.004) in Latina and NLB women. Further research should assess the association between G activity and health outcomes in a prospective cohort so as to characterize the relationship between total plasma G activity in pre-disease state and disease outcomes across different racial/ethnic populations.

Indexed as

Health Status DisparitiesAgedAged, 80 and overAlcohol DrinkingBlack or African AmericanFemaleHispanic or LatinoHumansLife StyleMiddle AgedMinority GroupsProspective StudiesReceptors, GlucocorticoidSan FranciscoSocioeconomic FactorsSurveys and QuestionnairesReceptors, Glucocorticoid

Identifiers

PMID32479509
PMCPMC7263601
OpenAlexW3029363639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.