Evidence map›Paper›PMID 32479323›Full record

ArticleJournal of affective disorders2020

Correlates, Course, and Outcomes of Increased Energy in Youth with Bipolar Disorder.

Elisabeth A Frazier, Jeffrey I Hunt, Heather Hower, Richard N Jones, Boris Birmaher, Michael Strober, Benjamin I Goldstein, Martin B Keller, Tina R Goldstein, Lauren M Weinstock and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Elisabeth A FrazierDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Bradley Hospital, 1011 Veterans Memorial Parkway, East Providence, RI, 02915, USA.
Jeffrey I HuntDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Bradley Hospital, 1011 Veterans Memorial Parkway, East Providence, RI, 02915, USA.
Heather HowerDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Department of Health Services, Policy, and Practice, Brown University School of Public Health, 121 South Main Street, Providence, RI, 02903, USA; Department of Psychiatry, School of Medicine, University of California San Diego, 4510 Executive Drive, San Diego, CA, 92123, USA. Electronic address: heather_hower@brown.edu.
Richard N JonesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA.
Boris BirmaherDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
Michael StroberDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Mail Code 175919, Los Angeles, CA, 90095, USA.
Benjamin I GoldsteinDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto Faculty of Medicine, 2075 Bayview Ave., FG-53, Toronto, ON, M4N-3M5, Canada.
Martin B KellerDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Butler Hospital, 700 Butler Drive, Providence, RI, 02906, USA.
Tina R GoldsteinDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
Lauren M WeinstockDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Butler Hospital, 700 Butler Drive, Providence, RI, 02906, USA.
Daniel P DicksteinDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Bradley Hospital, 1011 Veterans Memorial Parkway, East Providence, RI, 02915, USA.
Rasim S DilerDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
Neal D RyanDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
Mary Kay GillDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
David AxelsonDepartment of Psychiatry, Nationwide Children's Hospital and The Ohio State College of Medicine, 1670 Upham Dr., Columbus, OH, 43210, USA.
Shirley YenDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI, 02912, USA; Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02115, USA.

Funding

Course and Outcome of Bipolar Disorder in Youth - SupplementR01MH059929 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2000 to 2021
$15.9M
Course and Outcome for Bipolar Disorder in Youth (COBY)R01MH059691 · NIMH · BROWN UNIVERSITY · PI KELLER, MARTIN B, YEN, SHIRLEY · 2000 to 2015
$7.9M
Course and Outcome for Bipolar Disorder in YouthR01MH059977 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STROBER, MICHAEL A · 2000 to 2010
$3.7M
1/2 Predicting Adult Outcomes in Bipolar Youth (PROBY)R01MH112544 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2018 to 2022
$2.5M
2/2-Predicting Adult Outcomes in Bipolar Youth (PROBY)R01MH112543 · NIMH · BROWN UNIVERSITY · PI YEN, SHIRLEY · 2018 to 2022
$1.2M
NIMH NIH HHS R01 MH059691NIMH NIH HHS R01 MH059929NIMH NIH HHS R01 MH059977NIMH NIH HHS R01 MH112543NIMH NIH HHS R01 MH112544
6 · The paper itself

Abstract

objectivesCompare longitudinal trajectories of youth with Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV Bipolar Disorder (BD), grouped at baseline by presence/absence of increased energy during their worst lifetime mood episode (required for DSM-5).

methodsParticipants from the parent Course and Outcome of Bipolar Youth study (N = 446) were assessed utilizing The Schedule for Affective Disorders and Schizophrenia for School-Age Children (KSADS), KSADS Mania Rating Scale (KMRS), and KSADS Depression Rating Scale (KDRS). Youth were grouped at baseline into those with increased energy (meeting DSM-5 Criteria A for mania) vs. without increased energy (meeting DSM-IV, but not DSM-5, Criteria A for mania), for those who had worst lifetime mood episode recorded (n = 430). Youth with available longitudinal data had the presence/absence of increased energy measured, as well as psychiatric symptomatology/clinical outcomes (evaluated via the Adolescent Longitudinal Interval Follow-Up Evaluation), at each follow-up for 12.5 years (n = 398).

resultsAt baseline, the increased energy group (based on endorsed increased energy during worst lifetime mood episode; 86% of participants) vs. the without increased energy group, were more likely to meet criteria for BD-I and BD Not Otherwise Specified, had higher KMRS/KDRS total scores, and displayed poorer family/global psychosocial functioning. However, frequency of increased energy between groups was comparable after 5 years, and no significant group differences were found on clinical/psychosocial functioning outcomes after 12.5 years. LIMITATIONS: Secondary data limited study design; groupings were based on one time point.

conclusionsResults indicate no clinically relevant longitudinal group differences.

Indexed as

Bipolar DisorderAdolescentChildDiagnostic and Statistical Manual of Mental DisordersHumansPsychiatric Status Rating ScalesBipolar disorderChild and adolescent psychiatryIncreased energyLongitudinal studies

Identifiers

PMID32479323
PMCPMC7291830

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.