Evidence map›Paper›PMID 32479260›Full record

ArticleeLife2020

Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates.

Lei Yang, Michael Emerman, Harmit S Malik, Richard N McLaughlin

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lei YangPacific Northwest Research Institute, Seattle, United States.ORCID 0000-0001-9284-1744
Michael EmermanDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States.
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
Richard N McLaughlinPacific Northwest Research Institute, Seattle, United States.ORCID 0000-0003-0950-2253
Pacific Northwest Diabetes Research Institute · USFred Hutch Cancer Center · USHoward Hughes Medical Institute · US

Funding

Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
VPR AND HIV INFECTIONR01AI030927 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EMERMAN, MICHAEL · 1991 to 2020
$5.3M
Causes and human health consequences of the evolution of retroelements and host restriction factorsR00GM112941 · NIGMS · PACIFIC NORTHWEST RESEARCH INSTITUTE · PI MCLAUGHLIN, RICHARD NOEL · 2018 to 2020
$747k
Causes and human health consequences of the evolution of retroelements and host restriction factorsK99GM112941 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCLAUGHLIN, RICHARD NOEL · 2015 to 2016
$180k
National Institute of Allergy and Infectious Diseases AI3092NIAID NIH HHS R01 AI030927NIGMS NIH HHS GM074108NIGMS NIH HHS GM112941NIGMS NIH HHS K99 GM112941NIGMS NIH HHS R00 GM112941NIGMS NIH HHS R01 GM074108
6 · The paper itself

Abstract

Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which host genomes keep pace with rapidly evolving viruses. One family of restriction factors, the

Indexed as

APOBEC DeaminasesHost-Pathogen InteractionsAnimalsAntiviral AgentsGene DosageGene DuplicationHEK293 CellsHumansMutationPrimatesRetroelementsRetroviridaeAntiviral AgentsAPOBEC DeaminasesRetroelementsAPOBEC3evolutionary biologygenome defensegenome evolutioninfectious diseasemicrobiologyrestriction factorsretrogenestransposable elements

Identifiers

PMID32479260
PMCPMC7263822
OpenAlexW3029771624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.