Evidence map›Paper›PMID 32479175›Full record

ReviewAnnals of internal medicine2020

Research and Reporting Considerations for Observational Studies Using Electronic Health Record Data.

Alison Callahan, Nigam H Shah, Jonathan H Chen

Abstract readReview
In one paragraph

Review in Annals of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Digital Health Data Quality Issues: Systematic Review.Journal of medical Internet research · 2023
    Pooled it
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  17. A Standardized Guideline for Assessing Extracted Electronic Health Records Cohorts: A Scoping Review.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alison CallahanCenter for Biomedical Informatics Research, School of Medicine, Stanford University (A.C., N.H.S.).
Nigam H ShahCenter for Biomedical Informatics Research, School of Medicine, Stanford University (A.C., N.H.S.).
Jonathan H ChenDivision of Hospital Medicine, School of Medicine, Stanford University (J.H.C.).

Funding

Methods for generalized ontology terms enrichment analysisR01LM011369 · NLM · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2013 to 2020
$5.0M
Data-Mining Clinical Decision Support from Electronic Health RecordsK01ES026837 · NIEHS · STANFORD UNIVERSITY · PI CHEN, JONATHAN H. · 2015 to 2019
$893k
NIEHS NIH HHS K01 ES026837NLM NIH HHS R01 LM011369
6 · The paper itself

Abstract

Electronic health records (EHRs) are an increasingly important source of real-world health care data for observational research. Analyses of data collected for purposes other than research require careful consideration of data quality as well as the general research and reporting principles relevant to observational studies. The core principles for observational research in general also apply to observational research using EHR data, and these are well addressed in prior literature and guidelines. This article provides additional recommendations for EHR-based research. Considerations unique to EHR-based studies include assessment of the accuracy of computer-executable cohort definitions that can incorporate unstructured data from clinical notes and management of data challenges, such as irregular sampling, missingness, and variation across time and place. Principled application of existing research and reporting guidelines alongside these additional considerations will improve the quality of EHR-based observational studies.

Indexed as

Data CollectionElectronic Health RecordsHumansObservational Studies as TopicPrimary Health Care

Identifiers

PMID32479175
PMCPMC7413106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.