ArticleJournal of dental research2020
Interaction between the Oral Microbiome and Dental Composite Biomaterials: Where We Are and Where We Should Go.
Article in Journal of dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Influence of ZnO Nanoparticles on the Color and Surface Roughness of Composite and Glass-Ionomer Materials.Journal of functional biomaterials · 2026Article
- Simulated Body Fluids for Dental Implant Corrosion: A Practical Guide.Dentistry journal · 2026Review
- Effect of ammonia-free silver fluoride application on the resin-dentin interface subjected to an in situ cariogenic challenge.Clinical oral investigations · 2026Article
- Comparative Analysis of Erosion and Erosion-Abrasion Resistance of Bioactive Glass Ionomer-Based Restorative Materials: A Surface Characterization Study.Biomimetics (Basel, Switzerland) · 2026Article
- Influence of Polishing Protocols on Surface Roughness and Color Properties of a Zirconia-Based Nano-Hybrid Resin Composite.Journal of clinical and experimental dentistry · 2026Review
- TiOOdontology · 2025Article
- Exploring the Healing Powers of Histatins: From Oral Health to Therapeutics.International journal of molecular sciences · 2025Review
- Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties.Antibiotics (Basel, Switzerland) · 2025Article
- Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- Preservation Strategies for Interfacial Integrity in Restorative Dentistry: A Non-Comprehensive Literature Review.Journal of functional biomaterials · 2025Review
- Evaluation of early bacterial adhesion on CAD/CAM dental materials: an in situ study.Odontology · 2025Article
- Investigating the impact of whitening toothpastes on bioactive resin-based restorative materials: a comparative analysis.BMC oral health · 2024Article
- Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications.Dental materials : official publication of the Academy of Dental Materials · 2024Review
- Effect of elastic gradients on the fracture resistance of tri-layer restorative systems.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- A Historical Perspective on Dental Composite Restorative Materials.Journal of functional biomaterials · 2024Review
- Biofilm Formation on Hybrid, Resin-Based CAD/CAM Materials for Indirect Restorations: A Comprehensive Review.Materials (Basel, Switzerland) · 2024Review
- Oral Function and the Oral Microbiome in the Elderly in the Kyotango Area.Dentistry journal · 2024Article
- An introduction to antibacterial materials in composite restorations.JADA foundational science · 2024Article
- Article
- Salivary Pellicle Formed on Dental Composites Evaluated by Mass Spectrometry-An In Situ Study.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Dental composites are routinely placed as part of tooth restoration procedures. The integrity of the restoration is constantly challenged by the metabolic activities of the oral microbiome. This activity directly contributes to a less-than-desirable half-life for the dental composite formulations currently in use. Therefore, many new antimicrobial dental composites are being developed to counteract the microbial challenge. To ensure that these materials will resist microbiome-derived degradation, the model systems used for testing antimicrobial activities should be relevant to the in vivo environment. Here, we summarize the key steps in oral microbial colonization that should be considered in clinically relevant model systems. Oral microbial colonization is a clearly defined developmental process that starts with the formation of the acquired salivary pellicle on the tooth surface, a conditioned film that provides the critical attachment sites for the initial colonizers. Further development includes the integration of additional species and the formation of a diverse, polymicrobial mature biofilm. Biofilm development is discussed in the context of dental composites, and recent research is highlighted regarding the effect of antimicrobial composites on the composition of the oral microbiome. Future challenges are addressed, including the potential of antimicrobial resistance development and how this could be counteracted by detailed studies of microbiome composition and gene expression on dental composites. Ultimately, progress in this area will require interdisciplinary approaches to effectively mitigate the inevitable challenges that arise as new experimental bioactive composites are evaluated for potential clinical efficacy. Success in this area could have the added benefit of inspiring other fields in medically relevant materials research, since microbial colonization of medical implants and devices is a ubiquitous problem in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.