Evidence map›Paper›PMID 32479091›Full record

ArticleBiochemistry2020

Enzyme-Substrate-Cofactor Dynamical Networks Revealed by High-Resolution Field Cycling Relaxometry.

Masha M Rosenberg, Tianjiong Yao, Gregory C Patton, Alfred G Redfield, Mary F Roberts, Lizbeth Hedstrom

Abstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. High ResolutionFrontiers in molecular biosciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Masha M RosenbergDepartment of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.
Tianjiong YaoDepartment of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.
Gregory C PattonDepartment of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.
Alfred G RedfieldDepartment of Biochemistry, Brandeis University, MS009, 415 South Street, Waltham, Massachusetts 02453-9110, United States.
Mary F RobertsDepartment of Chemistry, Boston College, 140 Commonwealth Avenue, Chestnut Hill, Massachusetts 02467-9110, United States.
Lizbeth HedstromDepartment of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.ORCID 0000-0001-8432-3322

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
INOSINE MONOPHOSPHATE DEHYDROGENASER01GM054403 · NIGMS · BRANDEIS UNIVERSITY · PI HEDSTROM, LIZBETH K. · 1998 to 2016
$4.2M
NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM054403
6 · The paper itself

Abstract

The remarkable power and specificity of enzyme catalysis rely on the dynamic alignment of the enzyme, substrates, and cofactors, yet the role of dynamics has usually been approached from the perspective of the protein. We have been using an underappreciated NMR technique, subtesla high-resolution field cycling

Indexed as

CoenzymesGMP ReductaseNADPAmmoniaBiocatalysisGuanosine MonophosphateHumansKineticsMolecular ConformationMutationProtein BindingAmmoniaCoenzymesGMP ReductaseGuanosine MonophosphateNADP

Identifiers

PMID32479091
PMCPMC8364753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.