Evidence map›Paper›PMID 32478955›Full record

ArticleJournal of magnetic resonance imaging : JMRI2020

Deep-Learning-Based Artificial Intelligence for PI-RADS Classification to Assist Multiparametric Prostate MRI Interpretation: A Development Study.

Thomas Sanford, Stephanie A Harmon, Evrim B Turkbey, Deepak Kesani, Sena Tuncer, Manuel Madariaga, Chris Yang, Jonathan Sackett, Sherif Mehralivand, Pingkun Yan and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

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  4. Integrating Artificial Intelligence into Prostate MR Imaging: Technical Foundations, Clinical Applications, and Workflow Implications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Thomas SanfordMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Stephanie A HarmonClinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.
Evrim B TurkbeyDepartment of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Deepak KesaniMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sena TuncerMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Manuel MadariagaMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chris YangMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jonathan SackettMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sherif MehralivandMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Pingkun YanBiomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.
Sheng XuDepartment of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Bradford J WoodDepartment of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Maria J MerinoLaboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Peter A PintoUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Peter L ChoykeMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Baris TurkbeyMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Cancer Institute · USNational Institutes of Health · USDepartment of Health and Human Services · USFrederick National Laboratory for Cancer Research · USNational Institutes of Health Clinical Center · USRensselaer Polytechnic Institute · US

Funding

Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
Center for Interventional OncologyZIDBC011242 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOOD, BRADFORD J · 2009 to 2025
$18.7M
Prostate SectionZIABC011081 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PINTO, PETER · 2009 to 2025
$15.2M
Imaging, image guided biopsy and treatment of prostate cancerZIABC012062 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TÜRKBEY, BARIS · 2021 to 2025
$1.3M
Navigation Tools for Image Guided Minimally invasive TherapiesZIACL040011 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC012062NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

backgroundThe Prostate Imaging Reporting and Data System (PI-RADS) provides guidelines for risk stratification of lesions detected on multiparametric MRI (mpMRI) of the prostate but suffers from high intra/interreader variability. PURPOSE: To develop an artificial intelligence (AI) solution for PI-RADS classification and compare its performance with an expert radiologist using targeted biopsy results. STUDY TYPE: Retrospective study including data from our institution and the publicly available ProstateX dataset. POPULATION: In all, 687 patients who underwent mpMRI of the prostate and had one or more detectable lesions (PI-RADS score >1) according to PI-RADSv2. FIELD STRENGTH/SEQUENCE: T ASSESSMENT: PI-RADS lesions were segmented by a radiologist. Bounding boxes around the T STATISTICAL TESTS: Agreement between the AI and the radiologist-driven PI-RADS scores was assessed using a kappa score, and differences between categorical variables were assessed with a Wald test.

resultsFor the 1034 detection lesions, the kappa score for the AI system vs. the expert radiologist was moderate, at 0.40. However, there was no significant difference in the rates of detection of clinically significant cancer for any PI-RADS score in 86 patients undergoing targeted biopsy (P = 0.4-0.6). DATA

conclusionWe developed an AI system for assignment of a PI-RADS score on segmented lesions on mpMRI with moderate agreement with an expert radiologist and a similar ability to detect clinically significant cancer. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY STAGE: 2.

Indexed as

Deep LearningMultiparametric Magnetic Resonance ImagingProstatic NeoplasmsArtificial IntelligenceHumansMagnetic Resonance ImagingMaleRetrospective Studiesartificial intelligencedeep learningMRIPI-RADSprostate

Identifiers

PMID32478955
PMCPMC8942293
OpenAlexW3032695106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.