Evidence map›Paper›PMID 32478479›Full record

ArticleEarly intervention in psychiatry2021

Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis.

Drew Blasco, Saige William Stortz, Margaux Marie-Rose Grivel, Gabriella A Dishy, Shana S Samuel, David Pilla, Francesca M Crump, Sarah A Lieff, Jourdan Williams, Phetsamone Phoummavong and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Early intervention in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Preventive psychiatry: a blueprint for improving the mental health of young people.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Drew BlascoSchool of Global Public Health, New York University, New York, New York, USA.ORCID 0000-0003-2524-5066
Saige William StortzClinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
Margaux Marie-Rose GrivelSchool of Global Public Health, New York University, New York, New York, USA.
Gabriella A DishyClinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
Shana S SamuelClinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
David PillaClinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
Francesca M CrumpCenter of Prevention and Evaluation, New York State Psychiatric Institute, New York, New York, USA.
Sarah A LieffSchool of Global Public Health, New York University, New York, New York, USA.
Jourdan WilliamsClinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
Phetsamone PhoummavongNew York University, New York, New York, USA.
Xufei GuoClinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
Gary BrucatoColumbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York, USA.
Ragy R GirgisCollege of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York, USA.
Lawrence H YangSchool of Global Public Health, New York University, New York, New York, USA.ORCID 0000-0001-7779-7423
New York University · USNew York Psychoanalytic Society and Institute · USColumbia University · USColumbia University Irving Medical Center · USFordham University · USQueens College, CUNY · USThe Graduate Center, CUNY · US

Funding

Center for Research on the Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral GeneticsP50HG007257 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI APPELBAUM, PAUL STUART · 2013 to 2017
$5.4M
Biomarkers of Conversion Risk and Treatment Response in Early-Stage SchizophreniaR01MH110270 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2017 to 2021
$3.7M
The Neurobiology of Violence in a Psychosis-Risk CohortR01MH113861 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GIRGIS, RAGY RAMSIS · 2017 to 2021
$3.2M
Stigma Associated with a High-Risk State for PsychosisR01MH096027 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SUSSER, EZRA S., YANG, LAWRENCE H · 2012 to 2016
$2.6M
Developing Clinical Translational Tools to Communicate Genetic Risk to Individuals who are at Clinical High Risk for PsychosisR21HG010420 · NHGRI · NEW YORK UNIVERSITY · PI YANG, LAWRENCE H · 2019 to 2020
$470k
NHGRI NIH HHS P50 HG007257NHGRI NIH HHS R21 HG010420NIMH NIH HHS R01 MH096027NIMH NIH HHS R01 MH110270NIMH NIH HHS R01 MH113861
6 · The paper itself

Abstract

aimFuelled by genomics advances, recent emphasis on the concept of "precision medicine," and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts.

methodsSemistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed.

resultsParticipants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment.

conclusionsOur results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.

Indexed as

PsychiatryPsychotic DisordersGenetic TestingHumansOptimismclinical high-riskgenetic optimismgenetic testingprecision medicinepsychotic disorders

Identifiers

PMID32478479
PMCPMC9848423
OpenAlexW3032252983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.